Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

441 questions · 461 findings · 48 reviews

No studies found 76 · 16.5%GRADE not reported 94 · 20.4%Very low 82 · 17.8%Low 119 · 25.8%Moderate 73 · 15.8%High 17 · 3.7%

First‐line thiazides vs calcium channel blockers

Adverse effects (side effects; treatment withdrawals) · patients with hypertension

First‐line thiazides may leads to lower withdrawals due to adverse effects Duration: 1 to 5 years compared with first‐line calcium channel blockers (low certainty).

1 finding from 1 review

First‐line thiazides vs calcium channel blockers

Total serious adverse events Duration: 1.75 to 3 years · patients with hypertension

First‐line thiazides showed no clear difference in total serious adverse events Duration: 1.75 to 3 years compared with first‐line calcium channel blockers (low certainty).

1 finding from 1 review