Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,721 questions · 19,640 findings · 2,039 reviews · Headline outcomes only

No studies found 3,754 · 19.1%GRADE not reported 1,273 · 6.5%Very low 4,859 · 24.7%Low 5,568 · 28.4%Moderate 3,240 · 16.5%High 946 · 4.8%

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Antiplatelet agent vs control

Fatal or nonfatal myocardial infarction · people with chronic kidney disease (predialysis (GFR 15 to 60 mL/min/1.73 m²), HD, PD, transplant recipients)

Antiplatelet agents probably leads to lower fatal or nonfatal myocardial infarction compared with control (moderate certainty).

1 finding from 1 review

Antiplatelet agent vs control

Fatal or nonfatal stroke · people with chronic kidney disease (predialysis (GFR 15 to 60 mL/min/1.73 m²), HD, PD, transplant recipients)

It is very uncertain whether antiplatelet agents changes fatal or nonfatal stroke compared with control (very low certainty).

1 finding from 1 review

Antiplatelet agent vs control

Death (any cause) · people with chronic kidney disease (predialysis (GFR 15 to 60 mL/min/1.73 m²), HD, PD, transplant recipients)

Antiplatelet agents showed no clear difference in death (any cause) compared with control (low certainty).

1 finding from 1 review

Antiplatelet agent vs control

Cardiovascular mortality · people with chronic kidney disease (predialysis (GFR 15 to 60 mL/min/1.73 m²), HD, PD, transplant recipients)

It is very uncertain whether antiplatelet agents changes cardiovascular death compared with control (very low certainty).

1 finding from 1 review

Antiplatelet agent vs control

Major bleeding · people with chronic kidney disease (predialysis (GFR 15 to 60 mL/min/1.73 m²), HD, PD, transplant recipients)

Antiplatelet agents probably leads to higher major bleeding compared with control (moderate certainty).

1 finding from 1 review

Antiplatelet agent vs control

Minor bleeding · people with chronic kidney disease (predialysis (GFR 15 to 60 mL/min/1.73 m²), HD, PD, transplant recipients)

Antiplatelet agents may leads to higher minor bleeding compared with control (low certainty).

1 finding from 1 review

Antiplatelet agent vs control

Early access thrombosis (before 8 weeks) · people with chronic kidney disease (predialysis (GFR 15 to 60 mL/min/1.73 m²), HD, PD, transplant recipients)

Antiplatelet agents may leads to lower early access thrombosis (before 8 weeks) compared with control (low certainty).

1 finding from 1 review

Oral drug treatment vs topical treatments

Primary outcome 2: Clinical recurrence at 6 months · non‐pregnant women with a diagnosis of recurrent vulvovaginal candidiasis

It is very uncertain whether oral drug treatment changes primary outcome 2: Clinical recurrence at 6 months compared with topical drug treatment (very low certainty).

1 finding from 1 review