What do systematic reviews say?

Children: prednisolone vs dexamethasone

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 328 participants
  Very low
• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 533 participants
  GRADE not reported

Children: prednisolone vs dexamethasone

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 255 participants
  GRADE not reported

Children: prednisolone vs dexamethasone

Children: prednisolone showed no clear difference in new exacerbation during compared with dexamethasone (low certainty).

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  OR 0.85 [0.54, 1.34]
  4 studies · 981 participants
  Low

Adults: higher dose/longer course vs lower dose/shorter course

Adults: higher dose/longer course showed no clear difference in asthma symptoms Complete resolution by day 28 compared with lower dose/shorter course (low certainty).

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  OR 0.55 [0.13, 2.26]
  1 study · 35 participants
  Low

Adults: higher dose/longer course vs lower dose/shorter course

It is very uncertain whether adults: higher dose/longer course changes new exacerbation in compared with lower dose/shorter course (very low certainty).

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  OR 0.98 [0.17, 5.56]
  2 studies · 55 participants
  Very low
• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  OR 0.62 [0.23, 1.68]
  3 studies · 122 participants
  Low

Adults: higher dose/longer course vs lower dose/shorter course

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 41 participants
  Very low

Adults: higher dose/longer course vs lower dose/shorter course

It is very uncertain whether adults: higher dose/longer course changes all adverse events compared with lower dose/shorter course (very low certainty).

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  OR 4.15 [0.94, 18.41]
  1 study · 43 participants
  Very low

Adults: prednisolone vs dexamethasone

It is very uncertain whether adults: prednisolone changes re‐admission during compared with dexamethasone (very low certainty).

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  OR 0.35 [0.04, 3.47]
  1 study · 200 participants
  Very low

Adults: prednisolone vs dexamethasone

Adults: prednisolone showed no clear difference in asthma symptoms Returned to normal activities within 3 days compared with dexamethasone (low certainty).

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  OR 0.44 [0.19, 1.01]
  1 study · 191 participants
  Low

Dexketoprofen 25 mg plus tramadol 75 mg vs placebo

• Single fixed‐dose oral dexketoprofen plus tramadol for acute postoperative pain in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 748 participants
  Moderate

Dexketoprofen 25 mg plus tramadol 75 mg vs placebo

• Single fixed‐dose oral dexketoprofen plus tramadol for acute postoperative pain in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 62 participants
  Moderate

Dexketoprofen 25 mg plus tramadol 75 mg vs placebo

• Single fixed‐dose oral dexketoprofen plus tramadol for acute postoperative pain in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 123 participants
  Very low

Dexketoprofen 25 mg plus tramadol 75 mg vs placebo

• Single fixed‐dose oral dexketoprofen plus tramadol for acute postoperative pain in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 123 participants
  Very low

Dexketoprofen 25 mg plus tramadol 75 mg vs placebo

• Single fixed‐dose oral dexketoprofen plus tramadol for acute postoperative pain in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 123 participants
  Very low

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

(Infant outcomes) Any supplements containing iron showed no clear difference in low birthweight (less than 2500 g) (ALL) compared with same supplements without iron or no treatment/placebo (no iron or… (low certainty).

• Daily oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
  RR 0.84 [0.69, 1.03]
  11 studies · 17613 participants
  Low

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

It is very uncertain whether (Maternal outcomes) Any supplements containing iron changes maternal severe anaemia at any time during second and third… compared with same supplements without iron or no treatment/placebo (no iron or… (very low certainty).

• Daily oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
  RR 0.22 [0.01, 3.2]
  9 studies · 2125 participants
  Very low

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

(Maternal outcomes) Any supplements containing iron showed no clear difference in infection during pregnancy (including urinary tract infections) (ALL) compared with same supplements without iron or no treatment/placebo (no iron or… (low certainty).

• Daily oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
  RR 1.21 [0.33, 4.46]
  1 study · 727 participants
  Low

Any supplements containing iron and folic acid vs same supplements without iron nor folic acid (no iron nor folic acid or placebo)

(Infant outcomes) Any supplements containing iron and folic acid showed no clear difference in low birthweight (less than 2500 g) (ALL) compared with same supplements without iron nor folic acid (no iron nor folic acid… (low certainty).

• Daily oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
  RR 1.07 [0.31, 3.74]
  2 studies · 1311 participants
  Low

Any supplements containing iron and folic acid vs same supplements without iron nor folic acid (no iron nor folic acid or placebo)

• Daily oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1365 participants
  Moderate

Any supplements containing iron and folic acid vs same supplements without iron nor folic acid (no iron nor folic acid or placebo)

(Infant outcomes) Any supplements containing iron and folic acid showed no clear difference in preterm birth (less than 37 weeks of gestation) (ALL) compared with same supplements without iron nor folic acid (no iron nor folic acid… (low certainty).

• Daily oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
  RR 1.55 [0.4, 6]
  3 studies · 1497 participants
  Low