Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,734 questions · 15,288 findings · 893 reviews

No studies found 3,864 · 25.3%GRADE not reported 2,222 · 14.5%Very low 3,868 · 25.3%Low 3,280 · 21.5%Moderate 1,676 · 11%High 378 · 2.5%

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Calcineurin inhibitors ± oral steroids vs oral steroids alone

Adverse effects: diabetes or hyperglycaemia · minimal change disease in adults with nephrotic syndrome

Calcineurin inhibitors ± oral steroids showed no clear difference in adverse effects: diabetes or hyperglycaemia compared with oral steroids alone (low certainty).

1 finding from 1 review

Calcineurin inhibitors ± oral steroids vs oral steroids alone

Adverse effects: obesity or Cushing's Syndrome · minimal change disease in adults with nephrotic syndrome

Calcineurin inhibitors ± oral steroids may leads to lower adverse effects: obesity or Cushing's Syndrome compared with oral steroids alone (low certainty).

1 finding from 1 review

Mycophenolate sodium + oral steroids vs oral steroids alone

Complete remission · minimal change disease in adults with nephrotic syndrome

Mycophenolate sodium + oral steroids showed no clear difference in complete remission Time frame: 4 weeks compared with oral steroids alone (moderate certainty).

2 findings from 1 review

Mycophenolate sodium + oral steroids vs oral steroids alone

Complete or partial remission · minimal change disease in adults with nephrotic syndrome

Mycophenolate sodium + oral steroids showed no clear difference in complete or partial remission Time frame: 24 weeks to end of treatment compared with oral steroids alone (moderate certainty).

1 finding from 1 review

Mycophenolate sodium + oral steroids vs oral steroids alone

Adverse events: new‐onset glucose intolerance · minimal change disease in adults with nephrotic syndrome

Mycophenolate sodium + oral steroids showed no clear difference in adverse events: new‐onset glucose intolerance compared with oral steroids alone (low certainty).

1 finding from 1 review

Intervention not reported

Mobilityd ‐ overall analysis Using different mobility scales: MILA (range 0 to 36), EMS (range 0 to 20), BBS (range 0 to 56), PPME (range 0 to 12), Koval (range 1 to 7). Higher values indicate better mobility (except MILA and Koval, where scale wa... · adults following hip fracture surgery

The intervention may leads to higher mobilityd ‐ overall analysis Using different mobility scales: MILA… (low certainty).

1 finding from 1 review