What do systematic reviews say?

Resin composite restorations containing antibacterial agents vs Non-antibacterial containing composite restorations

The review found no eligible studies for this question.

• Antibacterial agents in composite restorations for the prevention of dental caries 2013 · Cochrane All outcomes
  No studies were included in this review, as we were unable to find any trials directly comparing antibacterial containing composites to other active interventions or controls.
  0 studies
  No studies found

Visual screening (oral visual inspection) by trained health workers vs No screening

• Screening programmes for the early detection and prevention of oral cancer 2013 · Cochrane All outcomes

  5-year survival
  A significantly higher five-year survival rate was reported in the screened group (55.5%) compared to the control (43.4%) (P value = 0.003).
  1 study · 523 participants
  GRADE not reported

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Prophylactic systemic antibiotics (amoxicillin) probably leads to lower implant failure compared with no antibiotics or placebo (moderate certainty).

• Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes

  4 months
  RR 0.33 [0.16, 0.67]
  6 studies · 1162 participants
  Moderate

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

The review found no eligible studies for this question.

• Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults 2013 · Cochrane All outcomes
  Not estimable. No included study assessed clinical attachment loss, a measure of progression of periodontitis. (See comment)
  0 studies
  No studies found

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in adverse events compared with no antibiotics or placebo; GRADE not reported.

• Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes

  3 to 5 months
  RR 1.0 [0.06, 15.85]
  6 studies · 1162 participants
  GRADE not reported

Camomile vs placebo

Camomile showed no clear difference in oral mucositis (any severity) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.89 [0.62, 1.27]
  1 study · 164 participants
  GRADE not reported

Indigo wood root vs saline placebo

Indigo wood root showed no clear difference in oral mucositis (moderate to severe) compared with saline (placebo); GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.75 [0.5, 1.1]
  1 study · 20 participants
  GRADE not reported

Sucralfate vs placebo or usual care

Sucralfate showed no clear difference in oral mucositis (any severity) compared with placebo/usual care (moderate certainty).

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.98 [0.88, 1.1]
  3 studies · 222 participants
  Moderate

Intestinal trefoil factor vs placebo

Intestinal trefoil factor showed no clear difference in oral mucositis (severe) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 1.52 [0.06, 36.39]
  1 study · 99 participants
  GRADE not reported

Zinc sulphate vs placebo

Zinc sulphate led to lower oral mucositis (severe) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.05 [0, 0.75]
  1 study · 27 participants
  GRADE not reported

Glutamine vs placebo or usual care

Glutamine showed no clear difference in oral mucositis (any severity) compared with placebo/usual care; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.78 [0.57, 1.08]
  5 studies
  GRADE not reported

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs No fluoride supplement (placebo or no treatment)

• Fluoride supplements (tablets, drops, lozenges or chewing gums) for preventing dental caries in children 2011 · Cochrane All outcomes

  24-36 months
  PF 0.24 [0.16, 0.33]
  3 studies · 1240 participants
  Moderate

Sucralfate vs placebo or usual care

Sucralfate probably leads to lower oral mucositis (severe) compared with placebo/usual care (moderate certainty).

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.67 [0.48, 0.92]
  7 studies · 428 participants
  Moderate

Low‐level laser therapy vs Placebo or no active treatment

Laser (low level) showed no clear difference in oral mucositis (any severity) compared with placebo/sham/no treatment; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.91 [0.71, 1.17]
  5 studies · 234 participants
  GRADE not reported

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs No fluoride supplement (placebo or no treatment)

• Fluoride supplements (tablets, drops, lozenges or chewing gums) for preventing dental caries in children 2011 · Cochrane All outcomes

  24-36 months
  PF 0.73 [0.46, 0.99]
  1 study · 115 participants
  Very low

Shenqi-fanghou vs no treatment

Shenqi-fanghou led to lower oral mucositis (severe) compared with no treatment; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.2 [0.11, 0.36]
  1 study · 140 participants
  GRADE not reported

Keratinocyte GF vs placebo

Keratinocyte GF led to lower oral mucositis (moderate to severe) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.74 [0.62, 0.89]
  7 studies
  GRADE not reported

Histamine gel vs placebo

Histamine gel showed no clear difference in oral mucositis (any severity) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 1.35 [0.91, 1.99]
  1 study · 39 participants
  GRADE not reported

Chlorhexidine vs placebo/no treatment

Chlorhexidine showed no clear difference in oral mucositis (any severity) compared with placebo/no treatment (low certainty).

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.76 [0.47, 1.24]
  4 studies · 454 participants
  Low

Shenqi-fanghou vs no treatment

Shenqi-fanghou led to lower oral mucositis (moderate to severe) compared with no treatment; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.51 [0.38, 0.68]
  1 study · 140 participants
  GRADE not reported