Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,006 questions · 3,171 findings · 607 reviews · Headline outcomes only

No studies found 411 · 13%GRADE not reported 153 · 4.8%Very low 968 · 30.5%Low 897 · 28.3%Moderate 589 · 18.6%High 153 · 4.8%

Low‐dose opioid based general anaesthesia vs high‐dose opioid based general anaesthesia

Mortality ‐ Death at any time after surgery · adult cardiac surgical patients

Low‐dose opioid‐based GA showed no clear difference in mortality ‐ Death at any time after surgery compared with high‐dose opioid‐based GA (low certainty).

1 finding from 1 review

Low‐dose opioid based general anaesthesia vs high‐dose opioid based general anaesthesia

Postoperative complications ‐ Myocardial infarction · adult cardiac surgical patients

Low‐dose opioid‐based GA showed no clear difference in postoperative myocardial infarction compared with high‐dose opioid‐based GA (low certainty).

1 finding from 1 review

Systematic screening vs no/opportunistic screening

All‐cause mortality · general population including those at moderate to high risk of CVD, mean age between 30 and 75

Systematic screening showed no clear difference in all‐cause mortality compared with no/opportunistic screening (low certainty).

1 finding from 1 review

Systematic screening vs no/opportunistic screening

Total coronary heart disease · general population including those at moderate to high risk of CVD, mean age between 30 and 75

Systematic screening showed no clear difference in coronary heart disease (total) compared with no/opportunistic screening (low certainty).

1 finding from 1 review