What do systematic reviews say?

Progesterone vs placebo/no treatment

Progesterone showed no clear difference in miscarriage rate per clinical pregnancy compared with placebo/no treatment (low certainty).

• Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
  RR 0.53 [0.25, 1.14]
  2 studies · 119 participants
  Low

Progesterone vs placebo/no treatment

Progesterone may leads to higher clinical pregnancy compared with placebo/no treatment (low certainty).

• Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
  RR 1.44 [1.04, 1.98]
  6 studies · 1073 participants
  Low

Progesterone vs placebo/no treatment

Progesterone showed no clear difference in multiple pregnancy compared with placebo/no treatment (low certainty).

• Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
  RR 0.58 [0.1, 3.55]
  2 studies · 586 participants
  Low

Progesterone vs placebo/no treatment

The review found no eligible studies for this question.

• Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Random forest classifier using KEGG Orthology features vs Caries versus healthy disease-state labels

The KEGG Orthology classifier had an approximate AUC of 0.75 in the disease-only study test set.

• Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. 2022 All outcomes

  Human oral samples
  AUC 0.75
  4 studies
  GRADE not reported

CBT vs alternative treatment

• Psychological therapies for temporomandibular disorders (TMDs) 2022 · Cochrane All outcomes
  SoF: 3 studies reported minor adverse events in the control group; 1 study reported minor adverse events in psychological therapy group; 1 study reported that there were no adverse events. Results: NCT00066937 minor…
  5 studies
  Very low

Study-specific random forest classifier vs Caries versus healthy disease-state labels

Bong-Soo 2017, Zhu 2018, and Jiang 2019 had mean AUC scores over 0.75; exact study-specific AUCs were not reported in text or readable figure labels.

• Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. 2022 All outcomes

  Human oral samples
  no estimate extracted
  15 studies
  GRADE not reported

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Systemic antibiotic prophylaxis (any regimen; topical therapy… may leads to lower dry socket compared with placebo (low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  1st to 7th day
  RR 0.66 [0.45, 0.97]
  13 studies · 1882 participants
  Low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Systemic antibiotic prophylaxis (any regimen; topical therapy… may leads to lower postsurgical infectious complications compared with placebo (low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  1st to 14th day
  RR 0.34 [0.19, 0.64]
  12 studies · 1728 participants
  Low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes swelling (7th day) compared with placebo (very low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  7th day
  RR 0.80 [0.50, 1.27]
  4 studies · 452 participants
  Very low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes pain (continuous, VAS 0-10 cm, 7th day) compared with placebo (very low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  6th to 7th day
  MD -0.26 [-0.59, 0.07]
  4 studies · 422 participants
  Very low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes presence of pain (dichotomous, yes/no on 6th-7th day) compared with placebo (very low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  6th to 7th day
  RR 0.59 [0.31, 1.12]
  3 studies · 675 participants
  Very low

Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo

Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 6 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).

• Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
  RR 0.8 [0.42, 1.55]
  1 study · 231 participants
  High

Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo

Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 12 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).

• Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
  RR 0.69 [0.4, 1.16]
  1 study · 231 participants
  High

Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo

Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 18 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).

• Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
  RR 0.72 [0.45, 1.16]
  1 study · 231 participants
  High

Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo

Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 24 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).

• Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
  RR 0.79 [0.51, 1.24]
  1 study · 231 participants
  High

Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo

The review found no eligible studies for this question.

• Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo

The review found no eligible studies for this question.

• Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo

The review found no eligible studies for this question.

• Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Continuous phenobarbital vs intermittent rectal or oral diazepam

The review found no eligible studies for this question.

• Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found