Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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Probiotics vs other active intervention

Grade ≥ 3 diarrhoea · participants with cancer treated with radiotherapy (with or without chemotherapy)

Probiotics may leads to lower severity of diarrhoea: grade 3 or higher compared with other active treatment (low certainty).

1 finding from 1 review

Probiotics vs other active intervention

Requiring rescue medication for diarrhoea · participants with cancer treated with radiotherapy (with or without chemotherapy)

It is very uncertain whether probiotics changes requiring rescue medication for diarrhoea compared with other active treatment (very low certainty).

1 finding from 1 review

Probiotics vs placebo

Median (mean) time to use of rescue medication · participants with cancer treated with radiotherapy (with or without chemotherapy)
2 findings from 1 review

Probiotics vs placebo

Requiring rescue medication for diarrhoea · participants with cancer treated with radiotherapy (with or without chemotherapy)

Probiotics showed no clear difference in requiring rescue medication for diarrhoea compared with placebo (moderate certainty).

2 findings from 1 review

Probiotics vs placebo

Adverse events · participants with cancer treated with radiotherapy (with or without chemotherapy)
2 findings from 1 review

Probiotics vs placebo

All‐cause mortality · participants with cancer treated with radiotherapy (with or without chemotherapy)
2 findings from 1 review