Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

418 questions · 611 findings · 68 reviews

No studies found 88 · 14.4%GRADE not reported 237 · 38.8%Very low 74 · 12.1%Low 115 · 18.8%Moderate 87 · 14.2%High 10 · 1.6%

TT genotype of AMELX rs6639060 vs CC + CT genotype of AMELX rs6639060

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC + CT genotype of AMELX rs6639060 and dental caries susceptibility (TT vs CC + CT model: OR 1.00, 95% CI 0.42-2.39) in the Ethnicity: Caucasian subgroup; certainty not graded.

3 findings from 1 review

Intervention not reported

Chronic lung disease ‒moderate to severe BPD · infants below 33 weeks of postmenstrual age who required resuscitation in the delivery room

It is very uncertain whether the intervention changes chronic lung disease ‒moderate to severe BPD (very low certainty).

1 finding from 1 review

Intervention not reported

Cranial ultrasound abnormalities ‒intraventricular haemorrhage grade 3 to 4 · infants below 33 weeks of postmenstrual age who required resuscitation in the delivery room

It is very uncertain whether the intervention changes cranial ultrasound abnormalities ‒intraventricular haemorrhage grade… (very low certainty).

1 finding from 1 review

Targeted individualized vs standard non‐individualized fortification

In‐hospital mortality · promoting growth and development in very low birth weight infants receiving human milk

It is very uncertain whether targeted individualized changes in‐hospital mortality compared with standard non‐individualized fortification (very low certainty).

1 finding from 1 review

Targeted individualized vs standard non‐individualized fortification

Necrotising enterocolitis · promoting growth and development in very low birth weight infants receiving human milk

It is very uncertain whether targeted individualized changes necrotizing enterocolitis compared with standard non‐individualized fortification (very low certainty).

1 finding from 1 review

Targeted individualized vs standard non‐individualized fortification

Culture‐proven late‐onset bacterial sepsis · promoting growth and development in very low birth weight infants receiving human milk

It is very uncertain whether targeted individualized changes culture‐proven late‐onset bacterial sepsis compared with standard non‐individualized fortification (very low certainty).

1 finding from 1 review