Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

458 questions · 466 findings · 48 reviews · Schizophrenia

No studies found 87 · 18.7%GRADE not reported 82 · 17.6%Very low 153 · 32.8%Low 111 · 23.8%Moderate 19 · 4.1%High 14 · 3%

Vitamin E vs placebo

Adverse effect: any · patients with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether VITAMIN E changes adverse effect: any compared with PLACEBO (very low certainty).

1 finding from 1 review

Vitamin E vs placebo

Leaving the study early · patients with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether VITAMIN E changes acceptability of treatment (measured by participants leaving the… compared with PLACEBO (very low certainty).

1 finding from 1 review

ARIPIPRAZOLE (IM) vs PLACEBO/NIL

Repeated need for tranquillisation ‐ needing additional injections during 24 hours · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether ARIPIPRAZOLE (IM) changes repeated need for tranquillisation ‐ needing additional injections… compared with PLACEBO/NIL (very low certainty).

1 finding from 1 review

ARIPIPRAZOLE (IM) vs PLACEBO/NIL

Specific behaviour: Agitation ‐ clinically important change (PANSS ‐EC reduction ≥ 40% from baseline) ‐ up to 2 hours · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether ARIPIPRAZOLE (IM) changes specific behaviour: Agitation ‐ clinically important change (PANSS… compared with PLACEBO/NIL (very low certainty).

1 finding from 1 review

ARIPIPRAZOLE (IM) vs PLACEBO/NIL

Global state: non‐responders to the first injection · psychosis‐induced aggression or agitation (rapid tranquillisation)

ARIPIPRAZOLE (IM) may leads to lower global state: non‐responders to the first injection compared with PLACEBO/NIL (low certainty).

1 finding from 1 review