Proportion of participants with 1 or more serious adverse events according to International Conference on Harmonisation Good Clinical Practice (ICH‐GCP) · adults admitted to the ICU
It is very uncertain whether higher changes proportion of participants with ≥ 1 serious adverse events according… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Quality of life (any measure): range 180 d to 1 y · adults admitted to the ICU
1 finding from 1 review
Lung injury diagnosed after randomisation (composite outcome): range 4 d to 23 d · adults admitted to the ICU
It is very uncertain whether higher changes lung injury diagnosed after randomisation (composite outcome): range… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Myocardial infarction · adults admitted to the ICU
It is very uncertain whether higher changes myocardial infarction diagnosed after randomisation: range ≤ 90 d compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Stroke · adults admitted to the ICU
It is very uncertain whether higher changes stroke diagnosed after randomisation: range 1 mo to 3 mo compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Sepsis diagnosed after randomisation: range 28 d to 60 d · adults admitted to the ICU
It is very uncertain whether higher changes sepsis diagnosed after randomisation: range 28 d to 60 d compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Mortality, near term corrected age or discharge · preterm infants
Lower showed no clear difference in mortality, near term corrected age or discharge compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).
1 finding from 1 review
Neurodevelopmental disability · preterm infants
Lower showed no clear difference in neurodevelopmental disability compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).
1 finding from 1 review
Intubation in the delivery room · preterm infants
Lower showed no clear difference in intubation in the delivery room compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).
1 finding from 1 review
Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · preterm infants
Lower showed no clear difference in severe retinopathy of prematurity (≥ stage 3) compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).
1 finding from 1 review
Severe intraventricular haemorrhage · preterm infants
Lower showed no clear difference in severe intraventricular haemorrhage (grade 3 or 4) compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).
1 finding from 1 review
Necrotising enterocolitis · preterm infants
Lower showed no clear difference in necrotising enterocolitis compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).
1 finding from 1 review
Chronic lung disease · preterm infants
It is very uncertain whether lower changes chronic lung disease (36 weeks' corrected age) compared with higher oxygen concentrations titrated to target oxygen saturations… (very low certainty).
1 finding from 1 review
Intervention not reported
Breathlessness ‐ all trials Lower score indicates improvement in breathlessness · patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy
1 finding from 1 review
Intervention not reported
Breathlessness ‐ subgroup analysis ‐ studies measuring during exercise test Lower score indicates improvement in breathlessness · patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy
1 finding from 1 review
Intervention not reported
Breathlessness ‐ subgroup analysis ‐ studies not measuring during exercise test Lower score indicates improvement in breathlessness · patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy
1 finding from 1 review
Intervention not reported
Health‐related quality of life ‐ all trials Higher scores indicate improved health‐related quality of life · patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy
1 finding from 1 review
Intervention not reported
Exercise capacity (5‐ or 6‐minute walking distance on cylinder air) · adults with COPD who had exertional dyspnoea but did not fulfil the criteria for long‐term oxygen treatment
1 finding from 1 review
Intervention not reported
Mortality · adults with COPD who had exertional dyspnoea but did not fulfil the criteria for long‐term oxygen treatment
The intervention showed no clear difference in mortality (moderate certainty).
1 finding from 1 review
Intervention not reported
Quality of life (dyspnoea) Measured on the CRQ, the output is a number from 0 to 7, where higher on the scale is better. MID is 0.5. · adults with COPD who had exertional dyspnoea but did not fulfil the criteria for long‐term oxygen treatment
The intervention probably leads to higher quality of life (dyspnoea) Measured on the CRQ, the output is a… (moderate certainty).
1 finding from 1 review