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Evidence found and GRADE certainty

954 questions · 963 findings · 130 reviews · Headline outcomes only

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No studies found 181 · 18.8%GRADE not reported 71 · 7.4%Very low 163 · 16.9%Low 311 · 32.3%Moderate 163 · 16.9%High 74 · 7.7%

Summary of findings 4: Efficacy and safety of IVT pegcetacoplan 8‐weekly (every other month) vs sham

Change in visual acuity (logMAR) ‐ 12 months (negative is better) · adults with GA due to AMD

Summary of findings 4: Efficacy and safety of IVT pegcetacoplan… showed no clear difference in change in BCVA from baseline at 1 year (ETDRS letters) compared with sham (moderate certainty).

1 finding from 1 review

Summary of findings 2: Efficacy and safety of IVT lampalizumab 6‐ to 8‐weekly (every other month) vs sham

Loss of ≥ 15 letters BCVA at 1 year · adults with GA due to AMD

Summary of findings 2: Efficacy and safety of IVT lampalizumab 6‐ to… showed no clear difference in loss of ≥ 15 letters BCVA at 1 year compared with sham (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Midwife continuity models vs other models of care

Fetal loss before 24 weeks gestation · childbearing women and their infants (all) (important/secondary outcomes)

It is very uncertain whether summary of findings table ‐ Midwife continuity models changes fetal loss before 24 weeks gestation compared with other models of care (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Midwife continuity models vs other models of care

Fetal loss at or after 24 weeks gestation · childbearing women and their infants (all) (important/secondary outcomes)

It is very uncertain whether summary of findings table ‐ Midwife continuity of care models changes fetal loss at or after 24 weeks gestation compared with other models of care (very low certainty).

1 finding from 1 review