Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

582 questions · 642 findings · 67 reviews · All outcomes

No studies found 173 · 26.9%GRADE not reported 298 · 46.4%Very low 121 · 18.8%Low 35 · 5.5%Moderate 15 · 2.3%High 0 · 0%

Prior application of silver diamine fluoride (SDF), with or without a rinsing step vs No prior SDF application (untreated dentin control)

Immediate bond strength (MPa) · Dental adhesives/resin composite bonded to dentin (in vitro), sound or caries-affected

Prior SDF application significantly reduces the immediate bond strength of adhesives to dentin overall (MD 7.12 MPa favoring untreated dentin, 95% CI 1.38 to 12.85; ungraded), with very high heterogeneity (I2=98%).

1 finding from 1 review

Prior SDF application with a rinsing step vs No prior SDF application (untreated dentin control)

Immediate bond strength (MPa) · Dental adhesives bonded to sound dentin (in vitro)

A rinsing step after SDF eliminates the negative effect on adhesive bond strength to sound dentin (MD 7.11 MPa, 95% CI -0.57 to 14.79, non-significant; ungraded).

1 finding from 1 review

Prior SDF application with a rinsing step vs No prior SDF application (untreated dentin control)

Immediate bond strength (MPa) · Dental adhesives bonded to caries-affected dentin (in vitro)

Prior SDF followed by a rinsing step significantly increases adhesive bond strength to caries-affected dentin (MD -4.79 MPa favoring SDF, 95% CI -9.19 to -0.40; ungraded).

1 finding from 1 review

Prior SDF application without a rinsing step vs No prior SDF application (untreated dentin control)

Immediate bond strength (MPa) · Dental adhesives bonded to caries-affected dentin (in vitro)

Only one study assessed SDF without a rinsing step on adhesive bonding to caries-affected dentin (Kucukyilmaz 2016, which reported impaired bond strength); no meta-analysis was possible, so no pooled estimate is available.

1 finding from 1 review

4% prilocaine plain vs 2% lidocaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

2 findings from 1 review

4% articaine, 1:100,000 epinephrine vs 2% mepivacaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

2 findings from 1 review

4% articaine, 1:200,000 epinephrine vs 4% articaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
2 findings from 1 review

3% prilocaine, 0.03 IU felypressin vs 2% lidocaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

2 findings from 1 review

4% articaine, 1:200,000 epinephrine vs 0.5% bupivacaine, 1:200,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
2 findings from 1 review

0.5% bupivacaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

2 findings from 1 review

2% mepivacaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

2 findings from 1 review

4% articaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Adverse effects: pain on injection (solution deposition), Heft-Parker VAS 0-170 mm · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

4% articaine, 1:100,000 epinephrine showed no clear difference in adverse effects: pain on injection (solution deposition),… compared with 2% lidocaine, 1:100,000 epinephrine (moderate certainty).

1 finding from 1 review

4% articaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

4% articaine, 1:100,000 epinephrine probably leads to higher adverse effects: pain following injection, Heft-Parker VAS 0-170 mm compared with 2% lidocaine, 1:100,000 epinephrine (moderate certainty).

1 finding from 1 review