Discriminant power for caries severity: mean difference in log10 CFU (microbial load) between lesion categories · Patients with dentine carious lesions (deciduous/permanent teeth; children and adults)
For yellow-vs-other colour compared with soft-vs-harder hardness, hardness was significantly the more discriminant test (pooled WMD -3.87, 95% CI -4.46 to -2.87; ungraded).
6 findings from 1 review
WMD -3.867 [-4.461, -2.874]
2 studies
GRADE not reported
WMD -4.446 [-5.241, -3.650]
2 studies
GRADE not reported
WMD -0.067 [-1.877, 1.743]
2 studies
GRADE not reported
Show 3 more findings
Only one study (Beighton et al.) permitted this comparison: the mean log10 CFU difference was 2.32 for the colour contrast (black vs rest) versus 3.72 for the hardness contrast (soft vs medium/hard); hardness appeared…
1 study
GRADE not reported
WMD -4.741 [-4.979, -4.502]
2 studies
GRADE not reported
WMD -3.369 [-3.595, -3.143]
2 studies
GRADE not reported
Treatment success (caries lesion arrest or restoration survival) · Children with dentin caries lesions in the outer half of dentin on occlusal surfaces of primary teeth
Conventional restorative treatment with resin composite gave a higher treatment success rate than resin sealing for outer-half occlusal dentin caries in primary teeth (2 studies; low certainty).
1 finding from 1 review
Treatment failure (annual failure rate) · Children (aged 5-8 years) with Class-II caries in primary molars, no pulp therapy
Etching dentine for 7 s rather than 15 s lowered bulk-fill composite failure (5.8% vs 16.9% annual failure) in one RCT; low quality of evidence (ungraded).
1 finding from 1 review
Collagen-degrading bacteria · Root caries lesion biofilm
Protein-degrading bacteria capable of degrading collagen were detected in root caries biofilm.
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Dentine caries in permanent molars (24 months) · Children and adolescents (general population, aged under 20 years)
1 finding from 1 review
SoF2: No evidence of a difference between interventions in caries after 1, 2 and 3 years; 995 (3 studies); Very low. Studies were clinically different so not combined in meta-analyses; 1 study (Tagliaferro 2011)…
3 studies · 995 participants
Very low
Dentine caries in permanent molars (24 months) · Children and adolescents (general population, aged under 20 years)
It is very uncertain whether resin-based fissure sealant plus fluoride varnish changes dentine caries in permanent molars (yes/no) compared with fluoride varnish alone (very low certainty).
1 finding from 1 review
Dentine caries in permanent molars (24 months) · Children and adolescents (general population, aged under 20 years)
It is very uncertain whether resin-based fissure sealant changes dentine caries in permanent molars (yes/no) compared with fluoride varnish (very low certainty).
1 finding from 1 review
Progression of caries lesion into enamel or dentine · Children with high risk of dental decay
The review found no eligible studies for this question.
1 finding from 1 review
No evidence found
0 studies
No studies found
Dentine caries in permanent molars (24 months) · Children and adolescents (general population, aged under 20 years)
1 finding from 1 review
Inconclusive results: two studies slightly favoured glass ionomers (Liu 2014b OR 0.46 (0.23-0.91); Tagliaferro 2011) evaluating 426 children; one study (Songpaisan 1995) found no difference (MD DFS -0.18 (-0.39 to…
3 studies · 830 participants
Very low
Dentine caries in permanent molars (24 months) · Children and adolescents (general population, aged under 20 years)
Resin-based fissure sealant (2nd/3rd/4th generation) probably leads to lower dentine caries in permanent molars (24 months) compared with no sealant (control/no treatment) (moderate certainty).
1 finding from 1 review
Dentine caries in permanent molars (24 months) · Children and adolescents (general population, aged under 20 years)
1 finding from 1 review
Inconsistent effect (differences in products, comparisons, outcomes, outcome reporting times, background fluoride and age groups); 21 trials (3883 participants randomised); very low quality
21 studies · 3883 participants
Very low
Dentine caries in permanent molars (24 months) · Children and adolescents (general population, aged under 20 years)
1 finding from 1 review
Caries (lesion) progression (radiographic) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…
Glass ionomer sealant (with fluoride gel plus dentifrice) showed no clear difference in caries (lesion) progression (radiographic) compared with fluoride gel plus fluoride toothpaste/dentifrice (non-invasive…; GRADE not reported.
1 finding from 1 review
OR 0.13 [0.01, 2.52]
1 study
GRADE not reported
Caries (lesion) progression (radiographic) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…
Adhesive/polyurethane sealant patch showed no clear difference in caries (lesion) progression (radiographic) compared with no treatment (both arms received flossing plus fluoride toothpaste); GRADE not reported.
1 finding from 1 review
OR 1.00 [0.14, 7.23]
1 study
GRADE not reported
Caries (lesion) progression (radiographic) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…
Micro-invasive treatment (proximal sealing or resin infiltration):… probably leads to lower caries (lesion) progression measured by pairwise reading of… compared with non-invasive measures (e.g. fluoride varnish, flossing/oral hygiene… (moderate certainty).
4 findings from 1 review
Show 1 more finding
OR 0.27 [0.17, 0.44]
5 studies
Moderate
Caries (lesion) progression (radiographic) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…
1 finding from 1 review
Caries (lesion) progression (radiographic) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…
Resin sealant (with or without flossing advice) led to lower caries (lesion) progression (radiographic) compared with flossing advice (non-invasive control); GRADE not reported.
1 finding from 1 review
OR 0.33 [0.18, 0.59]
2 studies
GRADE not reported
Caries (lesion) progression (radiographic) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…
Resin infiltration led to lower caries (lesion) progression (radiographic) compared with fluoride varnish, sham/placebo, or flossing advice (non-invasive…; GRADE not reported.
1 finding from 1 review
OR 0.19 [0.08, 0.46]
2 studies
GRADE not reported
Overall success (composite of clinical and radiographic success) · Vital permanent teeth (mature or immature) with deep or extremely deep caries and asymptomatic pulp or reversible pulpitis, undergoing…
At 36-month follow-up, HCSC show higher odds of clinical and radiographic success than CaOH (OR 2.34, 95% CI 1.43 to 3.84; ungraded subgroup).
3 findings from 1 review
OR 2.34 [1.43, 3.84]
2 studies · 379 participants
GRADE not reported
OR 4.44 [1.63, 12.07]
3 studies · 174 participants
GRADE not reported
OR 2.68 [1.7, 4.22]
5 studies · 552 participants
Moderate
Restoration longevity · Patients with deep caries lesions in mature or immature permanent (posterior) teeth, with no symptoms or reversible pulpitis
Cavity liners may make little or no difference to restoration longevity (high success across groups; low certainty).
1 finding from 1 review