Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,703 questions · 3,824 findings · 858 reviews

No studies found 573 · 15%GRADE not reported 383 · 10%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

Brushed less than twice per day vs Brushed twice or more per day

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years

It is very uncertain whether brushed less than twice per day changes fluorosis (percentage prevalence in permanent teeth) compared with brushed twice or more per day (very low certainty).

2 findings from 1 review

14 days on/off antibiotic regimen vs 14 days on/off placebo regimen

Exacerbation frequency · people with bronchiectasis

14 days on/off antibiotic regimen probably leads to lower exacerbation frequency compared with 14 days on/off placebo regimen (moderate certainty).

2 findings from 1 review

28 days on/off antibiotic regimen vs 28 days on/off placebo regimen

Pulmonary exacerbations: number of hospitalisations due to respiratory exacerbations · people with bronchiectasis

28 days on/off antibiotic regimen showed no clear difference in hospitalisation for pulmonary exacerbations compared with 28 days on/off placebo regimen (high certainty).

1 finding from 1 review