Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

864 questions · 884 findings · 229 reviews · Headline outcomes only

No studies found 136 · 15.4%GRADE not reported 37 · 4.2%Very low 242 · 27.4%Low 298 · 33.7%Moderate 131 · 14.8%High 40 · 4.5%

Psychosocial risk management ('Resettle' programme) vs usual care

Death during study period · adults with antisocial personality disorder

It is very uncertain whether psychosocial risk management ('Resettle' programme) changes adverse events: death during the study period Timing of assessment:… compared with treatment‐as‐usual (very low certainty).

1 finding from 1 review

Intervention not reported

Gait assessment · participants with relapsed or recurrent CTEV

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Gait assessment · participants with neglected CTEV

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Gait assessment · participants with CTEV (type of case (i.e. whether initial presentation or relapsed) not specified)

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Gait assessment · participants with CTEV at initial presentation

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Gait assessment · participants with resistant CTEV

The review found no eligible studies for this question.

1 finding from 1 review

Benzoyl peroxide vs placebo or no treatment

Participant's global self‐assessment of improvement (long‐term data) · participants with acne

Benzoyl peroxide may leads to higher participant's global self‐assessment of improvement (long‐term data) compared with placebo or no treatment (low certainty).

1 finding from 1 review

Benzoyl peroxide vs erythromycin

Participant's global self‐assessment of improvement (long‐term data) ‐ not measured · participants with acne

The review found no eligible studies for this question.

1 finding from 1 review

Benzoyl peroxide vs salicylic acid

Participant's global self‐assessment of improvement (long‐term data) ‐ not measured · participants with acne

The review found no eligible studies for this question.

1 finding from 1 review

Benzoyl peroxide vs adapalene

Participant's global self‐assessment of improvement (long‐term data) · participants with acne

Benzoyl peroxide showed no clear difference in participant's global self‐assessment of improvement (long‐term data) compared with adapalene (low certainty).

1 finding from 1 review

Benzoyl peroxide vs clindamycin

Participant's global self‐assessment of improvement (long‐term data) · participants with acne

Benzoyl peroxide showed no clear difference in participant's global self‐assessment of improvement (long‐term data) compared with clindamycin (low certainty).

1 finding from 1 review

Azelaic acid vs adapalene

Participants' global self‐assessment of acne improvement · participants with acne

It is very uncertain whether azelaic acid changes participants' global self‐assessment of acne improvement Improved to… compared with adapalene (very low certainty).

1 finding from 1 review

Azelaic acid vs tretinoin

Participants' global self‐assessment of acne improvement Good to excellent improvement (long term: treatment duration > 8 weeks) · participants with acne

Azelaic acid showed no clear difference in participants' global self‐assessment of acne improvement Good to… compared with tretinoin (moderate certainty).

1 finding from 1 review

Salicylic acid vs pyruvic acid

Participants' global self‐assessment of acne improvement Good to excellent improvement (medium term: treatment duration from 5 to 8 weeks) · participants with acne

It is very uncertain whether salicylic acid changes participants' global self‐assessment of acne improvement Good to… compared with pyruvic acid (very low certainty).

1 finding from 1 review