Findings

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Evidence found and GRADE certainty

4,815 questions · 6,211 findings · 638 reviews · Headline outcomes only

No studies found 1,052 · 16.9%GRADE not reported 441 · 7.1%Very low 1,700 · 27.4%Low 1,651 · 26.6%Moderate 1,070 · 17.2%High 297 · 4.8%

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Follow‐up integrating additional patient symptom education or monitoring, or survivorship care plans vs usual care

Overall survival · adult cancer survivors from the following cancer sites: breast, colorectal, endometrial, ovarian and prostate cancer

The review found no eligible studies for this question.

1 finding from 1 review

Follow‐up integrating additional patient symptom education or monitoring, or survivorship care plans vs usual care

Time to detection of recurrence · adult cancer survivors from the following cancer sites: breast, colorectal, endometrial, ovarian and prostate cancer

The review found no eligible studies for this question.

1 finding from 1 review

Non‐specialist‐led vs specialist‐led follow‐up after primary cancer treatment

Health‐related quality of life, (at 12 months' · adult cancer survivors from the following cancer sites: breast, colon, colorectal, endometrial, ovarian, cervical, melanoma and oesophageal

Non‐specialist‐led showed no clear difference in health‐related quality of life, (at 12 months' compared with specialist‐led follow‐up after primary cancer treatment (low certainty).

1 finding from 1 review

Non‐specialist‐led vs specialist‐led follow‐up after primary cancer treatment

Anxiety · adult cancer survivors from the following cancer sites: breast, colon, colorectal, endometrial, ovarian, cervical, melanoma and oesophageal

Non‐specialist‐led showed no clear difference in anxiety (at 12 months' compared with specialist‐led follow‐up after primary cancer treatment (moderate certainty).

1 finding from 1 review

Non‐specialist‐led vs specialist‐led follow‐up after primary cancer treatment

Depressive symptoms · adult cancer survivors from the following cancer sites: breast, colon, colorectal, endometrial, ovarian, cervical, melanoma and oesophageal

Non‐specialist‐led showed no clear difference in depression (at 12 months) HADS‐Depression subscale (higher scores… compared with specialist‐led follow‐up after primary cancer treatment (high certainty).

1 finding from 1 review

Thromboelastography threshold vs standard of care (laboratory parameters)

Major bleeding · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether thromboelastography threshold changes major bleeding within 24 hours № of participants: 60 (1 RCT) compared with standard of care (laboratory parameters) (very low certainty).

1 finding from 1 review

Thromboelastography threshold vs standard of care (laboratory parameters)

Number of individuals requiring a transfusion within 7 days № of participants: 60 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures

Thromboelastography threshold may leads to lower number of individuals requiring a transfusion within 7 days № of… compared with standard of care (laboratory parameters) (low certainty).

1 finding from 1 review

Thromboelastography threshold vs standard of care (laboratory parameters)

Serious adverse events measured by plasma transfusion‐related complications within 24 hours № of participants: 21 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether thromboelastography threshold changes serious adverse events measured by plasma transfusion‐related… compared with standard of care (laboratory parameters) (very low certainty).

1 finding from 1 review

Thromboelastography threshold vs standard of care (laboratory parameters)

Serious adverse events measured by surgery or procedure‐related complications within 30 days ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures

The review found no eligible studies for this question.

1 finding from 1 review

Cysteamine vs methionine (randomised trials)

Hepatotoxicity (aspartate aminotransferase > 1000 IU/L) · people with paracetamol (acetaminophen) overdose

It is very uncertain whether cysteamine changes hepatotoxicity (aspartate aminotransferase > 1000 U/L) compared with methionine (randomised trials) (very low certainty).

1 finding from 1 review