Findings

What do systematic reviews say?

3,006 questions · 3,171 findings · 607 reviews · Headline outcomes only

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No studies found 411 · 13%GRADE not reported 153 · 4.8%Very low 968 · 30.5%Low 897 · 28.3%Moderate 589 · 18.6%High 153 · 4.8%

Low tidal volume vs high tidal volume

Need for postoperative non‐invasive ventilatory support · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

Low tidal volume probably leads to lower need for postoperative non‐invasive ventilatory support compared with high tidal volume (moderate certainty).

1 finding from 1 review

Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of… 2018 · Cochrane Headline outcomes only
RR 0.31 [0.15, 0.64]
3 studies · 506 participants
Moderate

Low tidal volume vs high tidal volume

Need for postoperative invasive ventilatory support · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

Low tidal volume probably leads to lower need for postoperative invasive ventilatory support compared with high tidal volume (moderate certainty).

1 finding from 1 review

Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of… 2018 · Cochrane Headline outcomes only
RR 0.33 [0.14, 0.77]
11 studies · 957 participants
Moderate

Low tidal volume vs high tidal volume

ICU length of stay (general intensive care patients) · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

1 finding from 1 review

Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of… 2018 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 898 participants
Low

Low tidal volume vs high tidal volume

Length of hospital stay · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

1 finding from 1 review

Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of… 2018 · Cochrane Headline outcomes only
no estimate extracted
14 studies · 1298 participants
Low

Low tidal volume vs high tidal volume

Barotrauma (pneumothorax) · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

It is very uncertain whether low tidal volume changes barotrauma: pneumothorax compared with high tidal volume (very low certainty).

1 finding from 1 review

Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of… 2018 · Cochrane Headline outcomes only
RR 1.77 [0.52, 5.99]
5 studies · 708 participants
Very low

Intervention not reported

Major adverse cardiovascular events (MACE) · people with cardiovascular disease or at high risk of cardiovascular disease

The intervention probably leads to lower major adverse cardiovascular events (MACE) (moderate certainty).

1 finding from 1 review

Ezetimibe for the prevention of cardiovascular disease and all‐cause mortality events 2018 · Cochrane Headline outcomes only
RR 0.94 [0.9, 0.98]
10 studies · 21727 participants
Moderate

Intervention not reported

All‐cause mortality · people with cardiovascular disease or at high risk of cardiovascular disease

The intervention showed no clear difference in all‐cause mortality (high certainty).

1 finding from 1 review

Ezetimibe for the prevention of cardiovascular disease and all‐cause mortality events 2018 · Cochrane Headline outcomes only
RR 0.98 [0.91, 1.05]
8 studies · 21222 participants
High

Intervention not reported

Myocardial infarction (non‐fatal) · people with cardiovascular disease or at high risk of cardiovascular disease

The intervention probably leads to lower myocardial infarction (non‐fatal) (moderate certainty).

1 finding from 1 review

Ezetimibe for the prevention of cardiovascular disease and all‐cause mortality events 2018 · Cochrane Headline outcomes only
RR 0.88 [0.81, 0.95]
6 studies · 21145 participants
Moderate

Intervention not reported

Stroke (non‐fatal) · people with cardiovascular disease or at high risk of cardiovascular disease

The intervention probably leads to lower stroke (non‐fatal) (moderate certainty).

1 finding from 1 review

Ezetimibe for the prevention of cardiovascular disease and all‐cause mortality events 2018 · Cochrane Headline outcomes only
RR 0.83 [0.71, 0.97]
6 studies · 21205 participants
Moderate

Intervention not reported

Cardiovascular mortality · people with cardiovascular disease or at high risk of cardiovascular disease

The intervention showed no clear difference in cardiovascular mortality (moderate certainty).

1 finding from 1 review

Ezetimibe for the prevention of cardiovascular disease and all‐cause mortality events 2018 · Cochrane Headline outcomes only
RR 1 [0.89, 1.12]
6 studies · 19457 participants
Moderate

Intervention not reported

Adverse events ‐ hepatopathy · people with cardiovascular disease or at high risk of cardiovascular disease

The intervention showed no clear difference in adverse events ‐ hepatopathy (low certainty).

1 finding from 1 review

Ezetimibe for the prevention of cardiovascular disease and all‐cause mortality events 2018 · Cochrane Headline outcomes only
RR 1.14 [0.96, 1.35]
4 studies · 20687 participants
Low

Intervention not reported

Adverse events ‐ myopathy · people with cardiovascular disease or at high risk of cardiovascular disease

It is very uncertain whether the intervention changes adverse events ‐ myopathy (very low certainty).

1 finding from 1 review

Ezetimibe for the prevention of cardiovascular disease and all‐cause mortality events 2018 · Cochrane Headline outcomes only
RR 1.31 [0.72, 2.38]
3 studies · 20581 participants
Very low