Findings

What do systematic reviews say?

4,752 questions · 6,648 findings · 688 reviews

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No studies found 1,125 · 16.9%GRADE not reported 670 · 10.1%Very low 1,796 · 27%Low 1,685 · 25.3%Moderate 1,075 · 16.2%High 297 · 4.5%

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Summary of findings: ECM vs NECT plus cimetidine

Adverse events · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs NECT plus cimetidine

Pulmonary exacerbations · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fosfomycin plus imipenem vs vancomycin

All‐cause mortality during hospital stay and all‐cause mortality at 1 year · people with infective endocarditis due to methicillin‐resistant Staphylococcus aureus

It is very uncertain whether fosfomycin plus imipenem changes all‐cause mortality during hospital stay and all‐cause mortality at… compared with vancomycin (very low certainty).

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
RR 7 [0.47, 103.27]
1 study · 8 participants
Very low

Fosfomycin plus imipenem vs vancomycin

Cure · people with infective endocarditis due to methicillin‐resistant Staphylococcus aureus

It is very uncertain whether fosfomycin plus imipenem changes cure compared with vancomycin (very low certainty).

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
RR 0.5 [0.07, 3.55]
1 study · 8 participants
Very low

Fosfomycin plus imipenem vs vancomycin

Adverse events · people with infective endocarditis due to methicillin‐resistant Staphylococcus aureus

It is very uncertain whether fosfomycin plus imipenem changes adverse events compared with vancomycin (very low certainty).

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
RR 1 [0.25, 4]
1 study · 8 participants
Very low

Fosfomycin plus imipenem vs vancomycin

Congestive heart failure · people with infective endocarditis due to methicillin‐resistant Staphylococcus aureus

It is very uncertain whether fosfomycin plus imipenem changes congestive heart failure compared with vancomycin (very low certainty).

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
RR 9 [0.64, 126.85]
1 study · 8 participants
Very low

Fosfomycin plus imipenem vs vancomycin

Septic embolism · people with infective endocarditis due to methicillin‐resistant Staphylococcus aureus

The review found no eligible studies for this question.

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fosfomycin plus imipenem vs vancomycin

Need for cardiac surgical interventions · people with infective endocarditis due to methicillin‐resistant Staphylococcus aureus

It is very uncertain whether fosfomycin plus imipenem changes need for cardiac surgical interventions compared with vancomycin (very low certainty).

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
RR 2 [0.28, 14.2]
1 study · 8 participants
Very low

Fosfomycin plus imipenem vs vancomycin

Uncontrolled infection · people with infective endocarditis due to methicillin‐resistant Staphylococcus aureus

The review found no eligible studies for this question.

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Dihydrocodeine vs methadone

Abstinence · individuals dependent on illicit opiates

Dihydrocodeine showed no clear difference in abstinence compared with methadone (low certainty).

1 finding from 1 review

Dihydrocodeine for detoxification and maintenance treatment in individuals with opiate use disorders 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 204 participants
Low

Dihydrocodeine vs methadone

Retention in treatment · individuals dependent on illicit opiates

Dihydrocodeine showed no clear difference in treatment retention compared with methadone (low certainty).

1 finding from 1 review

Dihydrocodeine for detoxification and maintenance treatment in individuals with opiate use disorders 2020 · Cochrane Headline outcomes only
RR 1.04 [0.94, 1.16]
1 study · 204 participants
Low

Bakri balloon tamponade vs haemostatic square suturing to the lower segment of the uterus (intrauterine tamponade versus another mechanical/surgical method)

Mortality due to bleeding · women with complete placenta praevia and intractable bleeding following caesarean section

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Very low

Bakri balloon tamponade vs haemostatic square suturing to the lower segment of the uterus (intrauterine tamponade versus another mechanical/surgical method)

Hysterectomy to control bleeding · women with complete placenta praevia and intractable bleeding following caesarean section

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Very low

Bakri balloon tamponade vs haemostatic square suturing to the lower segment of the uterus (intrauterine tamponade versus another mechanical/surgical method)

Serious maternal morbidity (renal or respiratory failure, cardiac arrest or multiple organ failure) · women with complete placenta praevia and intractable bleeding following caesarean section

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Very low

Bakri balloon tamponade vs haemostatic square suturing to the lower segment of the uterus (intrauterine tamponade versus another mechanical/surgical method)

Number of women with total blood loss 1000 mL or more after randomisation · women with complete placenta praevia and intractable bleeding following caesarean section

The review found no eligible studies for this question.

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bakri balloon tamponade vs haemostatic square suturing to the lower segment of the uterus (intrauterine tamponade versus another mechanical/surgical method)

Mean blood loss (mL) (trialist defined) · women with complete placenta praevia and intractable bleeding following caesarean section

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Very low

Bakri balloon tamponade vs haemostatic square suturing to the lower segment of the uterus (intrauterine tamponade versus another mechanical/surgical method)

Blood transfusion (red cell or whole blood) · women with complete placenta praevia and intractable bleeding following caesarean section

It is very uncertain whether bakri balloon tamponade changes blood transfusion (red cell or whole blood) compared with haemostatic square suturing to the lower segment of the uterus… (very low certainty).

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
RR 0.57 [0.14, 2.36]
1 study · 13 participants
Very low

Bakri balloon tamponade vs haemostatic square suturing to the lower segment of the uterus (intrauterine tamponade versus another mechanical/surgical method)

Side effects of the intervention (e.g. trauma, necrosis) · women with complete placenta praevia and intractable bleeding following caesarean section

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Very low

Intrauterine balloon tamponade (condom‐loaded catheter) vs uterovaginal packing (intrauterine tamponade versus another intrauterine tamponade method)

Mortality due to bleeding · Women (aged between 20 and 40) diagnosed with primary PPH following 'normal' vaginal birth and unresponsive to medical treatment (Ashraf…

The review found no eligible studies for this question.

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intrauterine balloon tamponade (condom‐loaded catheter) vs uterovaginal packing (intrauterine tamponade versus another intrauterine tamponade method)

Hysterectomy to control bleeding · Women (aged between 20 and 40) diagnosed with primary PPH following 'normal' vaginal birth and unresponsive to medical treatment (Ashraf…

The review found no eligible studies for this question.

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found