Findings

What do systematic reviews say?

4,734 questions · 15,288 findings · 893 reviews

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No studies found 3,864 · 25.3%GRADE not reported 2,222 · 14.5%Very low 3,868 · 25.3%Low 3,280 · 21.5%Moderate 1,676 · 11%High 378 · 2.5%

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Intervention not reported

Vegetable consumption · children aged six months to six years

It is very uncertain whether the intervention changes vegetable consumption (very low certainty).

1 finding from 1 review

Healthy eating interventions delivered in early childhood education and care settings for improving the diet of… 2023 · Cochrane Headline outcomes only
SMD 0.12
13 studies · 3335 participants
Very low

Intervention not reported

Non‐core foods (i.e. less healthy or discretionary) consumption · children aged six months to six years

The intervention showed no clear difference in non‐core foods (i.e. less healthy or discretionary) consumption (moderate certainty).

1 finding from 1 review

Healthy eating interventions delivered in early childhood education and care settings for improving the diet of… 2023 · Cochrane Headline outcomes only
SMD 0.05
7 studies · 1369 participants
Moderate

Intervention not reported

Sugar‐sweetened beverage consumption · children aged six months to six years

The intervention showed no clear difference in sugar‐sweetened beverage consumption (moderate certainty).

1 finding from 1 review

Healthy eating interventions delivered in early childhood education and care settings for improving the diet of… 2023 · Cochrane Headline outcomes only
SMD 0.1
3 studies · 522 participants
Moderate

Intervention not reported

Cost‐effectiveness · children aged six months to six years

1 finding from 1 review

Healthy eating interventions delivered in early childhood education and care settings for improving the diet of… 2023 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 101 participants
Very low

Intervention not reported

Adverse consequences · children aged six months to six years

1 finding from 1 review

Healthy eating interventions delivered in early childhood education and care settings for improving the diet of… 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 62 participants
Very low

Sildenafil vs Placebo or no active treatment

All‐cause mortality · pregnant women with fetal growth restriction

Sildenafil citrate showed no clear difference in all‐cause mortality compared with placebo or no therapy (moderate certainty).

1 finding from 1 review

Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
RR 1.01 [0.8, 1.27]
5 studies · 516 participants
Moderate

Sildenafil vs IV nitroglycerin

All‐cause mortality · pregnant women with fetal growth restriction

1 finding from 1 review

Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 23 participants
Low

Sildenafil vs IV nitroglycerin

Fetal mortality · pregnant women with fetal growth restriction

1 finding from 1 review

Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 23 participants
Low

Sildenafil vs IV nitroglycerin

Neonatal mortality · pregnant women with fetal growth restriction

1 finding from 1 review

Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 23 participants
Low

Sildenafil vs Placebo or no active treatment

Fetal mortality · pregnant women with fetal growth restriction

Sildenafil citrate showed no clear difference in fetal mortality compared with placebo or no therapy (moderate certainty).

1 finding from 1 review

Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
RR 0.82 [0.6, 1.12]
5 studies · 516 participants
Moderate

Sildenafil vs Placebo or no active treatment

Neonatal mortality · pregnant women with fetal growth restriction

Sildenafil citrate showed no clear difference in neonatal mortality compared with placebo or no therapy (moderate certainty).

1 finding from 1 review

Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
RR 1.45 [0.9, 2.33]
5 studies · 397 participants
Moderate

Tadalafil vs Placebo or no active treatment

All‐cause mortality · pregnant women with fetal growth restriction

Tadalafil showed no clear difference in all‐cause mortality compared with placebo or no therapy (low certainty).

1 finding from 1 review

Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
RR 0.2 [0.02, 1.6]
1 study · 87 participants
Low

Tadalafil vs Placebo or no active treatment

Fetal mortality · pregnant women with fetal growth restriction

Tadalafil showed no clear difference in fetal mortality compared with placebo or no therapy (low certainty).

1 finding from 1 review

Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
RR 0.11 [0.01, 1.96]
1 study · 87 participants
Low

Tadalafil vs Placebo or no active treatment

Neonatal mortality · pregnant women with fetal growth restriction

Tadalafil showed no clear difference in neonatal mortality compared with placebo or no therapy (low certainty).

1 finding from 1 review

Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
RR 0.89 [0.06, 13.7]
1 study · 83 participants
Low

Nitroglycerin vs Placebo or no active treatment

All‐cause mortality · pregnant women with fetal growth restriction

1 finding from 1 review

Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 23 participants
Low

Nitroglycerin vs Placebo or no active treatment

Fetal mortality · pregnant women with fetal growth restriction

1 finding from 1 review

Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 23 participants
Low

Nitroglycerin vs Placebo or no active treatment

Neonatal mortality · pregnant women with fetal growth restriction

1 finding from 1 review

Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 23 participants
Low

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Functional independence · people with acute ischemic stroke

Thrombo‐aspiration alone showed no clear difference in functional independence at 3 months (mRS 0 to 2) (primary outcome) compared with stent‐retrieval thrombectomy alone (high certainty).

1 finding from 1 review

Different types of percutaneous endovascular interventions for acute ischemic stroke 2023 · Cochrane Headline outcomes only
RR 0.97 [0.82, 1.13]
2 studies · 633 participants
High

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Successful reperfusion (mTICI 2b to 3) postprocedure · people with acute ischemic stroke

Thrombo‐aspiration alone showed no clear difference in successful reperfusion (mTICI 2b to 3) postprocedure compared with stent‐retrieval thrombectomy alone (high certainty).

1 finding from 1 review

Different types of percutaneous endovascular interventions for acute ischemic stroke 2023 · Cochrane Headline outcomes only
RR 1.01 [0.95, 1.07]
2 studies · 650 participants
High

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

All‐cause mortality within 3 months · people with acute ischemic stroke

Thrombo‐aspiration alone showed no clear difference in all‐cause mortality within 3 months compared with stent‐retrieval thrombectomy alone (high certainty).

1 finding from 1 review

Different types of percutaneous endovascular interventions for acute ischemic stroke 2023 · Cochrane Headline outcomes only
RR 1.01 [0.74, 1.37]
2 studies · 633 participants
High