Findings

What do systematic reviews say?

4,815 questions · 6,211 findings · 638 reviews · Headline outcomes only

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No studies found 1,052 · 16.9%GRADE not reported 441 · 7.1%Very low 1,700 · 27.4%Low 1,651 · 26.6%Moderate 1,070 · 17.2%High 297 · 4.8%

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Summary of findings: ECM vs NECT plus cimetidine

Change in height · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs NECT plus cimetidine

Change in BMI · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs NECT plus cimetidine

Abdominal pain frequency or change in frequency · adults with cystic fibrosis

It is very uncertain whether summary of findings: ECM changes frequency in bowel symptoms: abdominal pain (% of days affected) compared with NECT plus cimetidine (very low certainty).

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Very low

Summary of findings: ECM vs NECT plus cimetidine

CFA: change in FFE (g/day) · adults with cystic fibrosis

Summary of findings: ECM showed no clear difference in CFA: change in FFE (g/day) compared with NECT plus cimetidine (low certainty).

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Low

Summary of findings: ECM vs NECT plus cimetidine

Adverse events · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs NECT plus cimetidine

Pulmonary exacerbations · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fosfomycin plus imipenem vs vancomycin

All‐cause mortality during hospital stay and all‐cause mortality at 1 year · people with infective endocarditis due to methicillin‐resistant Staphylococcus aureus

It is very uncertain whether fosfomycin plus imipenem changes all‐cause mortality during hospital stay and all‐cause mortality at… compared with vancomycin (very low certainty).

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
RR 7 [0.47, 103.27]
1 study · 8 participants
Very low

Fosfomycin plus imipenem vs vancomycin

Cure · people with infective endocarditis due to methicillin‐resistant Staphylococcus aureus

It is very uncertain whether fosfomycin plus imipenem changes cure compared with vancomycin (very low certainty).

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
RR 0.5 [0.07, 3.55]
1 study · 8 participants
Very low

Fosfomycin plus imipenem vs vancomycin

Adverse events · people with infective endocarditis due to methicillin‐resistant Staphylococcus aureus

It is very uncertain whether fosfomycin plus imipenem changes adverse events compared with vancomycin (very low certainty).

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
RR 1 [0.25, 4]
1 study · 8 participants
Very low

Fosfomycin plus imipenem vs vancomycin

Congestive heart failure · people with infective endocarditis due to methicillin‐resistant Staphylococcus aureus

It is very uncertain whether fosfomycin plus imipenem changes congestive heart failure compared with vancomycin (very low certainty).

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
RR 9 [0.64, 126.85]
1 study · 8 participants
Very low

Fosfomycin plus imipenem vs vancomycin

Septic embolism · people with infective endocarditis due to methicillin‐resistant Staphylococcus aureus

The review found no eligible studies for this question.

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fosfomycin plus imipenem vs vancomycin

Need for cardiac surgical interventions · people with infective endocarditis due to methicillin‐resistant Staphylococcus aureus

It is very uncertain whether fosfomycin plus imipenem changes need for cardiac surgical interventions compared with vancomycin (very low certainty).

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
RR 2 [0.28, 14.2]
1 study · 8 participants
Very low

Fosfomycin plus imipenem vs vancomycin

Uncontrolled infection · people with infective endocarditis due to methicillin‐resistant Staphylococcus aureus

The review found no eligible studies for this question.

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Dihydrocodeine vs methadone

Abstinence · individuals dependent on illicit opiates

Dihydrocodeine showed no clear difference in abstinence compared with methadone (low certainty).

1 finding from 1 review

Dihydrocodeine for detoxification and maintenance treatment in individuals with opiate use disorders 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 204 participants
Low

Dihydrocodeine vs methadone

Retention in treatment · individuals dependent on illicit opiates

Dihydrocodeine showed no clear difference in treatment retention compared with methadone (low certainty).

1 finding from 1 review

Dihydrocodeine for detoxification and maintenance treatment in individuals with opiate use disorders 2020 · Cochrane Headline outcomes only
RR 1.04 [0.94, 1.16]
1 study · 204 participants
Low

Bakri balloon tamponade vs haemostatic square suturing to the lower segment of the uterus (intrauterine tamponade versus another mechanical/surgical method)

Mortality due to bleeding · women with complete placenta praevia and intractable bleeding following caesarean section

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Very low

Bakri balloon tamponade vs haemostatic square suturing to the lower segment of the uterus (intrauterine tamponade versus another mechanical/surgical method)

Hysterectomy to control bleeding · women with complete placenta praevia and intractable bleeding following caesarean section

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Very low

Bakri balloon tamponade vs haemostatic square suturing to the lower segment of the uterus (intrauterine tamponade versus another mechanical/surgical method)

Serious maternal morbidity (renal or respiratory failure, cardiac arrest or multiple organ failure) · women with complete placenta praevia and intractable bleeding following caesarean section

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Very low

Bakri balloon tamponade vs haemostatic square suturing to the lower segment of the uterus (intrauterine tamponade versus another mechanical/surgical method)

Number of women with total blood loss 1000 mL or more after randomisation · women with complete placenta praevia and intractable bleeding following caesarean section

The review found no eligible studies for this question.

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bakri balloon tamponade vs haemostatic square suturing to the lower segment of the uterus (intrauterine tamponade versus another mechanical/surgical method)

Mean blood loss (mL) (trialist defined) · women with complete placenta praevia and intractable bleeding following caesarean section

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Very low