Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,345 questions · 4,525 findings · 483 reviews

No studies found 1,024 · 22.6%GRADE not reported 388 · 8.6%Very low 1,172 · 25.9%Low 1,227 · 27.1%Moderate 576 · 12.7%High 138 · 3%

Perioperative chemotherapy vs primary surgery

Overall survival by chemo‐/radiotherapy ‐ Chemoradiotherapy · resectable adenocarcinoma of the stomach, gastroesophageal junction, and lower esophagus

Perioperative chemotherapy probably leads to lower overall survival by chemo‐/radiotherapy ‐ Chemoradiotherapy compared with primary surgery (moderate certainty).

1 finding from 1 review

Intervention not reported

Perioperative mortality · people with pancreatic surgery

It is very uncertain whether the intervention changes perioperative mortality (very low certainty).

1 finding from 1 review

Intervention not reported

Treatment withdrawal · people with pancreatic surgery

It is very uncertain whether the intervention changes treatment withdrawal (very low certainty).

1 finding from 1 review

Intervention not reported

Re‐operation · people with pancreatic surgery

It is very uncertain whether the intervention changes re‐operation (very low certainty).

1 finding from 1 review

Intervention not reported

Anastomotic leak · people with pancreatic surgery

The intervention showed no clear difference in anastomotic leak; GRADE not reported.

1 finding from 1 review

Intervention not reported

Pancreatic fistula (clinically significant) · people with pancreatic surgery

It is very uncertain whether the intervention changes pancreatic fistula (clinically significant) (very low certainty).

1 finding from 1 review

Intervention not reported

Infected abdominal collections · people with pancreatic surgery

The intervention showed no clear difference in infected abdominal collections; GRADE not reported.

1 finding from 1 review

Intervention not reported

Shock · people with pancreatic surgery

The intervention showed no clear difference in shock; GRADE not reported.

1 finding from 1 review

Fibrin glue instillation under skin flaps vs no‐fibrin

Incidence of postoperativeseromaRR · people with breast and axillary surgery

Fibrin glue instillation under skin flaps showed no clear difference in incidence of postoperativeseromaRR compared with no‐fibrin (low certainty).

1 finding from 1 review

Fibrin glue instillation under skin flaps vs no‐fibrin

PostoperativecomplicationsRR · people with breast and axillary surgery

Fibrin glue instillation under skin flaps showed no clear difference in postoperativecomplicationsRR compared with no‐fibrin (low certainty).

1 finding from 1 review