Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,288 questions · 3,354 findings · 516 reviews · Headline outcomes only

No studies found 720 · 21.5%GRADE not reported 164 · 4.9%Very low 950 · 28.3%Low 932 · 27.8%Moderate 434 · 12.9%High 154 · 4.6%

Reduced dose of antipsychotics vs antipsychotic maintenance

Tardive dyskinesia: Deterioration of symptoms · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia

It is very uncertain whether reduced dose of antipsychotics changes tardive dyskinesia: deterioration of symptoms compared with antipsychotic maintenance (very low certainty).

1 finding from 1 review

Switch to a specific antipsychotic vs switch to a different specific antipsychotic

Social confidence, social inclusion, social networks, or personalised quality of life ‐ not reported · patients with antipsychotic‐induced tardive dyskinesia

The review found no eligible studies for this question.

1 finding from 1 review

Specific antipsychotic vs other drugs

Tardive dyskinesia: No clinically important improvement · patients with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether specific antipsychotic changes tardive dyskinesia: not improved to a clinically important extent compared with other drugs (very low certainty).

1 finding from 1 review

Specific antipsychotic vs other drugs

Tardive dyskinesia: Deterioration of symptoms · patients with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether specific antipsychotic changes tardive dyskinesia: deterioration of symptoms compared with other drugs (very low certainty).

1 finding from 1 review

Specific antipsychotic vs other drugs

Leaving the study early · patients with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether specific antipsychotic changes acceptability of the treatment: leaving the study early compared with other drugs (very low certainty).

1 finding from 1 review

Reduced dose of antipsychotics vs antipsychotic maintenance

General mental state: relapse · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia

It is very uncertain whether reduced dose of antipsychotics changes general mental state: relapse compared with antipsychotic maintenance (very low certainty).

1 finding from 1 review

Reduced dose of antipsychotics vs antipsychotic maintenance

Leaving the study early · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia

It is very uncertain whether reduced dose of antipsychotics changes acceptability of the treatment: leaving the study early compared with antipsychotic maintenance (very low certainty).

1 finding from 1 review

Reduced dose of antipsychotics vs antipsychotic maintenance

Social confidence, social inclusion, social networks, or personalised quality of life ‐ not reported · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia
1 finding from 1 review

Switch to another antipsychotic vs antipsychotic cessation

Tardive dyskinesia: No clinically important improvement · psychiatric patients (schizophrenia) with antipsychotic‐induced tardive dyskinesia

Switch to another antipsychotic may leads to lower tardive dyskinesia: no clinically important improvement compared with antipsychotic cessation (low certainty).

1 finding from 1 review

Therapeutic contact lens vs topical lubrication

Resolution of symptoms · people with recurrent corneal erosion syndrome without previous surgical intervention

Therapeutic contact lens showed no clear difference in resolution of symptoms after treatment compared with topical lubrication (low certainty).

1 finding from 1 review