Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,556 questions · 2,794 findings · 119 reviews · Oral Health

No studies found 489 · 17.5%GRADE not reported 1,719 · 61.5%Very low 399 · 14.3%Low 128 · 4.6%Moderate 58 · 2.1%High 1 · 0%

Inlay autogenous bone graft (iliac crest) vs Inlay bone substitute (Bio-Oss block)

Vertical bone gain · Patients with atrophic posterior mandibles (5 to 7 mm above the mandibular canal) needing implants

Inlay autogenous bone graft (iliac crest) showed no clear difference in vertical bone gain compared with inlay bone substitute (Bio-Oss block); GRADE not reported.

1 finding from 1 review

Calcitonin (salmon calcitonin nasal spray 200 IU/day) vs placebo

Increase in volume of more than 10% compared to the pretreatment measurement · Patients with histologically confirmed CGCG in one or both jaws and normal serum calcium and parathyroid hormone (PTH) levels

Calcitonin (salmon calcitonin nasal spray 200 IU/day) showed no clear difference in increase in volume of more than 10% compared to the pretreatment… compared with placebo; GRADE not reported.

1 finding from 1 review

Prophylactic aciclovir (oral or intravenous) vs placebo

Amount of analgesia · Patients being treated for cancer (predominantly haematological malignancies)

The review found no eligible studies for this question.

1 finding from 1 review

Aciclovir (oral or intravenous) for treatment vs placebo

Recurrence of lesions · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)

The review found no eligible studies for this question.

1 finding from 1 review

Aciclovir (oral or intravenous) for treatment vs placebo

Duration of viral shedding · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)
1 finding from 1 review

Prophylactic aciclovir (oral or intravenous) vs placebo

Patient quality of life · Patients being treated for cancer (predominantly haematological malignancies)

The review found no eligible studies for this question.

1 finding from 1 review

Aciclovir (oral or intravenous) for treatment vs placebo

Relief of pain · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)
1 finding from 1 review

Any denture cleansing method (mechanical or chemical) vs Another method, sham/placebo, or no treatment

Outcome not reported · Adults (over 18) wearing complete dentures (CD) or removable partial dentures (RPD)
1 finding from 1 review
  • Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
    Although six RCTs were included in this review, the wide range of different interventions and outcome variables did not permit pooling of data in a meta-analysis. Isolated reports indicated that chemicals and brushing…
    6 studies
    GRADE not reported

Inlay autogenous bone graft (iliac crest) vs Autogenous onlay bone graft (iliac crest)

Graft failure · Patients with deficient posterior mandibles (4.5 to 10 mm above the mandibular canal) needing implants

Autogenous inlay bone graft (iliac crest) showed no clear difference in graft failure compared with autogenous onlay bone graft (iliac crest); GRADE not reported.

1 finding from 1 review

Calcitonin (salmon calcitonin nasal spray 200 IU/day) vs placebo

Adverse events · Patients with histologically confirmed CGCG in one or both jaws and normal serum calcium and parathyroid hormone (PTH) levels
1 finding from 1 review
  • Adverse events were not described separately for each group. Trialists reported that adverse events were in most patients minimal and consisted of nausea, flushes and some dizziness. One patient had diarrhoea which…
    1 study · 14 participants
    GRADE not reported

Brushing vs no treatment

Total anaerobes (colony forming units, log-transformed) · Maxillary complete denture (CD) wearers

Brushing led to lower total anaerobes (colony forming units, log-transformed) compared with no treatment; GRADE not reported.

1 finding from 1 review

Effervescent tablets vs no treatment

Fusobacteria (colony forming units, log-transformed) · Maxillary complete denture (CD) wearers

Effervescent tablets led to lower fusobacteria (colony forming units, log-transformed) compared with no treatment; GRADE not reported.

1 finding from 1 review

1-stage (non-submerged) implant placement vs 2-stage (submerged) implant placement

Aesthetics evaluated by dentists (soft tissue recession) · People with dental implants

1-stage (non-submerged) implant placement showed no clear difference in aesthetics evaluated by dentists (soft tissue recession) compared with 2-stage (submerged) implant placement; GRADE not reported.

1 finding from 1 review

Inlay autogenous bone graft (iliac crest) vs Inlay bone substitute (Bio-Oss block)

Patient preference · Patients with atrophic posterior mandibles (5 to 7 mm above the mandibular canal) needing implants

Inlay autogenous bone graft (iliac crest) led to lower patient preference compared with inlay bone substitute (Bio-Oss block); GRADE not reported.

1 finding from 1 review

Prophylactic valaciclovir (lower dose) vs Prophylactic valaciclovir (higher dose)

Presence/absence of HSV oral lesions · Patients being treated for cancer (acute leukaemia; chemotherapy or stem-cell transplantation)

Prophylactic valaciclovir (lower dose) showed no clear difference in presence/absence of HSV oral lesions compared with prophylactic valaciclovir (higher dose); GRADE not reported.

1 finding from 1 review

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

Experienced the operation negatively · Patients with atrophic (resorbed) mandibles needing implants

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… showed no clear difference in experienced the operation negatively compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

1 finding from 1 review

Brushing vs no treatment

Fusobacteria (colony forming units, log-transformed) · Maxillary complete denture (CD) wearers

Brushing led to lower fusobacteria (colony forming units, log-transformed) compared with no treatment; GRADE not reported.

1 finding from 1 review

Brushing vs Effervescent tablets

Fusobacteria (colony forming units, log-transformed) · Maxillary complete denture (CD) wearers

Brushing led to higher fusobacteria (colony forming units, log-transformed) compared with effervescent tablets; GRADE not reported.

1 finding from 1 review

Aciclovir (oral or intravenous) for treatment vs placebo

Length of hospital stay · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)

The review found no eligible studies for this question.

1 finding from 1 review

Inlay autogenous bone graft (iliac crest) vs Inlay bone substitute (Bio-Oss block)

Implant failure · Patients with atrophic posterior mandibles (5 to 7 mm above the mandibular canal) needing implants

Inlay autogenous bone graft (iliac crest) showed no clear difference in implant failure compared with inlay bone substitute (Bio-Oss block); GRADE not reported.

1 finding from 1 review