Search review questions

Adverse events other than severe hypoglycaemic episodes (all non‐severe hypoglycaemic episodes) (Events per participant per month)

HbA1c (%)

Health‐related quality of life (different scales used)

Socioeconomic effects

All‐cause mortality · people at increased risk of developing type 2 diabetes mellitus

Serious adverse events · people at increased risk of developing type 2 diabetes mellitus

Cardiovascular mortality · people at increased risk of developing type 2 diabetes mellitus

Non‐fatal myocardial infarction/stroke · people at increased risk of developing type 2 diabetes mellitus

Health‐related quality of life · people at increased risk of developing type 2 diabetes mellitus

Socioeconomic effects · people at increased risk of developing type 2 diabetes mellitus

All‐cause mortality · people at increased risk of developing type 2 diabetes mellitus

Incidence of type 2 diabetes mellitus Definition: 1 trial: FPG ≥ 7.8 mmol/L or a 2‐hour plasma glucose ≥ 11.1 mmol/L after a 75 g OGTT (Da Qing 1997). 1 trial FPG > 6.9 mmol/L and/or 2‐hour plasma glucose concentration > 12.1 mmol/L (Hellgren 2016) · people at increased risk of developing type 2 diabetes mellitus

Serious adverse events · people at increased risk of developing type 2 diabetes mellitus

Cardiovascular mortality · people at increased risk of developing type 2 diabetes mellitus

Non‐fatal myocardial infarction/stroke Description: non‐fatal myocardial infarction/stroke · people at increased risk of developing type 2 diabetes mellitus

Incidence of type 2 diabetes mellitus Diagnostic criteria: 3 trials applied the WHO 1985 criteria (FPG ≥ 7.8 mmol/L or a 2‐hour glucose ≥ 11.1 mmol/L after a 75 g OGTT) (Da Qing 1997; DPS 2001; Oldroyd 2005). 3 trials applied the WHO 1999 criteria... · people at increased risk of developing type 2 diabetes mellitus

Health‐related quality of life Definition: measured by two questions (grading total physical and mental health from 1 to 7; grading general health from 1 (best) to 5 (very bad)) · people at increased risk of developing type 2 diabetes mellitus

Socioeconomic effects · people at increased risk of developing type 2 diabetes mellitus

Serious adverse events (SAE) · people at increased risk of developing type 2 diabetes mellitus

Cardiovascular mortality · people at increased risk of developing type 2 diabetes mellitus

Non‐fatal myocardial infarction/stroke · people at increased risk of developing type 2 diabetes mellitus

Health‐related quality of life Description: SF‐36 to evaluate the SF‐6D, PCS and MCS MID was defined as difference in scores between groups of at least 3% · people at increased risk of developing type 2 diabetes mellitus

Socioeconomic effects Description: direct medical costs of the interventions · people at increased risk of developing type 2 diabetes mellitus

All‐cause mortality · people at increased risk of developing type 2 diabetes mellitus

Incidence of type 2 diabetes mellitus Definition: WHO 1985 criteria · people at increased risk of developing type 2 diabetes mellitus

Diabetes‐related distress PAID and DDS scales

Health‐related quality of life Various questionnaires

Adverse events Self‐reported outcomes

Self‐efficacy Various questionnaires

HbA1c (%)

Diabetes‐related complications

All‐cause mortality Medical records or reported by family members

All‐cause mortality · people at risk for development of T2DM

Serious adverse events · people at risk for development of T2DM

Cardiovascular mortality · people at risk for development of T2DM

(1) Non‐fatal myocardial infarction (2) Non‐fatal stroke (3) Congestive heart failure · people at risk for development of T2DM

Health‐related quality of life SF‐36 scale: total score 0‐100, 8 subscales. Higher values mean better health‐related quality of life. · people at risk for development of T2DM

Socioeconomic effects · people at risk for development of T2DM

Incidence of T2DM Definition: WHO criteria · people at risk for development of T2DM

Serious adverse events · people at risk for development of T2DM

Cardiovascular mortality · people at risk for development of T2DM

(1) Non‐fatal myocardial infarction (2) Non‐fatal stroke (3) Congestive heart failure · people at risk for development of T2DM

Health‐related quality of life · people at risk for development of T2DM

Socioeconomic effects · people at risk for development of T2DM

All‐cause mortality · people at risk for development of T2DM

Incidence of T2DM Definition/description: 1 trial established the diagnosis of T2DM defined as HbA1c ≥ 6.5%, or fasting plasma glucose ≥ 7.0 mmol/L, or 2‐hour plasma glucose post‐challenge (oral glucose tolerance test) ≥ 11.1 mmol/L (SCALE). Other... · people at risk for development of T2DM

Change in BMI (kg/m²) · children (aged 6 to 11 years) being overweight or obese

Adverse events (serious adverse events) · children (aged 6 to 11 years) being overweight or obese

Change in health‐related quality of life (SMD) Parent‐reported measures Instruments: PedsQL parent proxy: 23 items that yield total, physical summary, and psychosocial summary scores, each with a possible range of 0‐100 (100 = best possible health... · children (aged 6 to 11 years) being overweight or obese

All‐cause mortality · children (aged 6 to 11 years) being overweight or obese