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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,590 questions in 129 reviews · Gynaecological, Neuro-oncology and Orphan Cancer
current versionsNo studies 281 · 17.7%Ungraded 74 · 4.7%Very low 410 · 25.8%Low 420 · 26.4%Moderate 280 · 17.6%High 125 · 7.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy Overall survival for subgroup aged ≥ 60 years glioblastoma · people with high grade glioma External beam radiation dose escalation for high grade glioma (2020) · Cochrane | HR 1.16 [0.92, 1.46] | 2 studies · 293 participants | High |
Hormone replacement therapy (HRT) vs no HRT Overall survival Hormone replacement therapy after surgery for epithelial ovarian cancer (2020) · Cochrane | HR 0.71 [0.54, 0.93] | 3 studies · 350 participants | Low |
Hormone replacement therapy (HRT) vs no HRT Quality of life, general condition Hormone replacement therapy after surgery for epithelial ovarian cancer (2020) · Cochrane | no estimate extracted | 1 study · 75 participants | Very low |
Hormone replacement therapy (HRT) vs no HRT Progression‐free survival Hormone replacement therapy after surgery for epithelial ovarian cancer (2020) · Cochrane | HR 0.76 [0.57, 1.01] | 2 studies · 275 participants | Low |
Hormone replacement therapy (HRT) vs no HRT Incidence of breast cancer Hormone replacement therapy after surgery for epithelial ovarian cancer (2020) · Cochrane | RR 2 [0.19, 21.59] | 2 studies · 225 participants | Very low |
Hormone replacement therapy (HRT) vs no HRT Incidence of transient ischaemic attack Hormone replacement therapy after surgery for epithelial ovarian cancer (2020) · Cochrane | RR 5 [0.24, 102.42] | 1 study · 150 participants | Very low |
Hormone replacement therapy (HRT) vs no HRT Incidence of cerebrovascular accident Hormone replacement therapy after surgery for epithelial ovarian cancer (2020) · Cochrane | RR 0.67 [0.11, 3.88] | 1 study · 150 participants | Very low |
Hormone replacement therapy (HRT) vs no HRT Incidence of myocardial infarction Hormone replacement therapy after surgery for epithelial ovarian cancer (2020) · Cochrane | RR 0.2 [0.01, 4.1] | 1 study · 150 participants | Very low |
Hormone replacement therapy (HRT) vs no HRT Incidence of gallstones Hormone replacement therapy after surgery for epithelial ovarian cancer (2020) · Cochrane | no estimate extracted | NR | No studies |
Anti‐EGFR therapy vs placebo or standard of care Overall survival ‐ first‐line studies · glioblastoma in adults Anti‐epidermal growth factor receptor therapy for glioblastoma in adults (2020) · Cochrane | HR 0.89 [0.76, 1.04] | 3 studies · 1000 participants | Moderate |
Anti‐EGFR therapy vs placebo or standard of care Overall survival ‐ recurrent disease studies · glioblastoma in adults Anti‐epidermal growth factor receptor therapy for glioblastoma in adults (2020) · Cochrane | HR 0.79 [0.51, 1.21] | 4 studies · 489 participants | Low |
Anti‐EGFR therapy vs placebo or standard of care Lymphopenia · glioblastoma in adults Anti‐epidermal growth factor receptor therapy for glioblastoma in adults (2020) · Cochrane | OR 0.97 [0.19, 4.81] | 4 studies · 1146 participants | Low |
Anti‐EGFR therapy vs placebo or standard of care Neutropenia · glioblastoma in adults Anti‐epidermal growth factor receptor therapy for glioblastoma in adults (2020) · Cochrane | OR 1.29 [0.82, 2.03] | 4 studies · 1146 participants | Low |
Anti‐EGFR therapy vs placebo or standard of care Thrombocytopenia · glioblastoma in adults Anti‐epidermal growth factor receptor therapy for glioblastoma in adults (2020) · Cochrane | OR 3.69 [0.51, 26.51] | 4 studies · 1146 participants | Low |
Anti‐EGFR therapy vs placebo or standard of care Progression‐free survival ‐ first‐line studies · glioblastoma in adults Anti‐epidermal growth factor receptor therapy for glioblastoma in adults (2020) · Cochrane | HR 0.94 [0.81, 1.1] | 2 studies · 894 participants | Low |
Anti‐EGFR therapy vs placebo or standard of care Progression‐free survival ‐ recurrent disease studies · glioblastoma in adults Anti‐epidermal growth factor receptor therapy for glioblastoma in adults (2020) · Cochrane | HR 0.75 [0.58, 0.96] | 3 studies · 275 participants | Low |
Intervention NR Overall survivala · adult women with symptoms of endometrial cancer Health education interventions to promote early presentation and referral for women with symptoms of… (2020) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Disease‐free survivalb · adult women with symptoms of endometrial cancer Health education interventions to promote early presentation and referral for women with symptoms of… (2020) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Delayed referralc · adult women with symptoms of endometrial cancer Health education interventions to promote early presentation and referral for women with symptoms of… (2020) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Delayed presentationd · adult women with symptoms of endometrial cancer Health education interventions to promote early presentation and referral for women with symptoms of… (2020) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Referral time (days)e · adult women with symptoms of endometrial cancer Health education interventions to promote early presentation and referral for women with symptoms of… (2020) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Presentation time (days)f · adult women with symptoms of endometrial cancer Health education interventions to promote early presentation and referral for women with symptoms of… (2020) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Supportive care only*** (1 RCT, 81 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40);… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | no estimate extracted | 1 study · 81 participants | Ungraded |
Intervention NR TMZ (3 RCTs, 538 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | HR 0.95 [0.71, 1.26] | 3 studies · 538 participants | Low |
Intervention NR CRT (2 RCTs; 635 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | HR 0.67 [0.56, 0.8] | 2 studies · 635 participants | High |
Intervention NR BEV_CRT (1 RCT; 73 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | HR 0.56 [0.31, 0.99] | 1 study · 73 participants | Moderate |
Intervention NR RT 60 (5 RCTs; 713 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40);… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | no estimate extracted | 5 studies · 60 participants | Ungraded |
Intervention NR RT 40 (4 RCTs; 930 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40);… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | HR 0.94 [0.72, 1.23] | 4 studies · 40 participants | Low |
Intervention NR BEV_RT (1 RCT; 75 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40);… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | HR 1.01 [0.58, 1.79] | 1 study · 75 participants | Very low |
Intervention NR TMZ (3 RCTs, 538 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40);… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | HR 0.89 [0.71, 1.11] | 3 studies · 538 participants | Very low |
Intervention NR CRT (2 RCTs; 635 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40);… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | HR 0.63 [0.46, 0.87] | 2 studies · 635 participants | Low |
Intervention NR BEV_CRT (1 RCT; 73 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40);… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | HR 0.52 [0.28, 0.98] | 1 study · 73 participants | Ungraded |
Intervention NR RT vs supportive care only · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | no estimate extracted | 1 study · 59 participants | Low |
Intervention NR RT60 (5 RCTs; 713 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40);… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | HR 0.47 [0.29, 0.76] | 5 studies · 60 participants | Moderate |
Intervention NR Hypofractionated RT vs standard RT (60Gy/30 fractions) · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | no estimate extracted | 2 studies · 85 participants | Low |
Intervention NR TMZ vs RT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | no estimate extracted | 1 study · 306 participants | Moderate |
Intervention NR CRT vs RT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | no estimate extracted | 1 study · 562 participants | Ungraded |
Intervention NR BEV_CRT vs CRT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | no estimate extracted | 1 study · 73 participants | Ungraded |
Intervention NR BEV_RT vs RT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | no estimate extracted | 1 study · 75 participants | Ungraded |
Intervention NR RIN_CRT vs control/CRT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | no estimate extracted | 1 study · 174 participants | Ungraded |
Intervention NR TTF_AC vs CRT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | no estimate extracted | 1 study · 134 participants | Ungraded |
Intervention NR IRI_BEV_RT vs CRT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | no estimate extracted | 1 study · 34 participants | Ungraded |
Intervention NR RT vs supportive care only · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | HR 0.28 [0.17, 0.46] | 1 study · 81 participants | Moderate |
Intervention NR Hypofractionated RT vs standard RT (60Gy/30 fractions) · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | no estimate extracted | 1 study · 64 participants | Ungraded |
Intervention NR BEV_RT (1 RCT; 75 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40);… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | HR 0.48 [0.23, 1] | 1 study · 75 participants | Ungraded |
Intervention NR TMZ vs RT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | HR 1.15 [0.92, 1.44] | 1 study · 373 participants | Low |
Intervention NR CRT vs RT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | HR 0.5 [0.41, 0.61] | 1 study · 562 participants | High |
Intervention NR BEV_CRT vs CRT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | HR 0.78 [0.46, 1.32] | 1 study · 73 participants | Low |
Intervention NR BEV_RT vs RT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | HR 0.46 [0.27, 0.78] | 1 study · 75 participants | Moderate |
Intervention NR RIN_CRT vs CRT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative… Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis (2020) · Cochrane | no estimate extracted | NR | No studies |