Nausea · adults with cancer‐related pain
CR oxycodone showed no clear difference in nausea (Event rate during treatment, length of treatment varied… compared with CR morphine (low certainty).
1 finding from 1 review
Vomiting · adults with cancer‐related pain
It is very uncertain whether CR oxycodone changes vomiting (Event rate during treatment, length of treatment varied… compared with CR morphine (very low certainty).
1 finding from 1 review
Quality of life · adults with cancer‐related pain
It is very uncertain whether CR oxycodone changes quality of life compared with CR morphine (very low certainty).
1 finding from 1 review
Participant preference · adults with cancer‐related pain
1 finding from 1 review
Constipation · adults with cancer‐related pain
It is very uncertain whether CR oxycodone changes constipation (Event rate during treatment, length of treatment… compared with IR oxycodone (very low certainty).
1 finding from 1 review
Drowsiness/somnolence (Event rate during treatment, length of treatment varied across trials) · adults with cancer‐related pain
It is very uncertain whether CR oxycodone changes drowsiness/somnolence (Event rate during treatment, length of… compared with IR oxycodone (very low certainty).
1 finding from 1 review
Nausea · adults with cancer‐related pain
It is very uncertain whether CR oxycodone changes nausea (Event rate during treatment, length of treatment varied… compared with IR oxycodone (very low certainty).
1 finding from 1 review
Vomiting · adults with cancer‐related pain
It is very uncertain whether CR oxycodone changes vomiting (Event rate during treatment, length of treatment varied… compared with IR oxycodone (very low certainty).
1 finding from 1 review
Quality of life · adults with cancer‐related pain
1 finding from 1 review
Participant preference · adults with cancer‐related pain
The review found no eligible studies for this question.
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults with cancer‐related pain
CR oxycodone may leads to higher pain intensity (various pain intensity scales; SMD) compared with CR morphine (low certainty).
1 finding from 1 review
Laxation response: risk of spontaneous rescue‐free bowel movements in the short terma · people with cancer irrespective of whether receiving palliative care and with opioid‐induced bowel dysfunction
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Symptoms of opioid withdrawal in the medium term · people with cancer irrespective of whether receiving palliative care and with opioid‐induced bowel dysfunction
Low dose naldemedine showed no clear difference in symptoms of opioid withdrawalfin the medium termb compared with higher doses (low certainty).
1 finding from 1 review
Serious adverse eventsg · people with cancer irrespective of whether receiving palliative care and with opioid‐induced bowel dysfunction
Low dose naldemedine showed no clear difference in serious adverse eventsg compared with higher doses (low certainty).
1 finding from 1 review
Adverse events · people with cancer irrespective of whether receiving palliative care and with opioid‐induced bowel dysfunction
Low dose naldemedine showed no clear difference in adverse events compared with higher doses (low certainty).
1 finding from 1 review
Laxation response: risk of spontaneous rescue‐free bowel movements in the short terma · people with cancer and receiving palliative care with opioid‐induced bowel dysfunction
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Laxation response: risk of spontaneous rescue‐free bowel movements in the medium termb · people with cancer and receiving palliative care with opioid‐induced bowel dysfunction
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Laxation response: patient assessment of change in bowel status at the end of trial · people with cancer and receiving palliative care with opioid‐induced bowel dysfunction
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Symptoms of opioid withdrawal in the medium term · people with cancer and receiving palliative care with opioid‐induced bowel dysfunction
1 finding from 1 review
Serious adverse events · people with cancer and receiving palliative care with opioid‐induced bowel dysfunction
1 finding from 1 review