Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

332 questions · 398 findings · 53 reviews

No studies found 114 · 28.6%GRADE not reported 115 · 28.9%Very low 66 · 16.6%Low 69 · 17.3%Moderate 30 · 7.5%High 4 · 1%

440 to 550 ppm F toothpaste vs 250 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

440 to 550 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 250 ppm F toothpaste (low certainty).

1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Filled primary surfaces at 3 years · Pregnant women (for preventing dental caries in the primary teeth of their children)

Fluoride supplementation (tablets, drops, lozenges or chewing gum) showed no clear difference in filled primary surfaces at 5 years compared with placebo or no treatment; GRADE not reported.

2 findings from 1 review

Resin-based fissure sealant (2nd/3rd/4th generation) vs No sealant (control/no treatment)

Caries on occlusal surfaces of permanent molars (12 months) · Children and adolescents (general population, aged under 20 years)

Resin-based fissure sealant (2nd/3rd/4th generation) led to lower caries on occlusal surfaces of permanent molars (36 months) compared with no sealant (control/no treatment); GRADE not reported.

3 findings from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Decayed primary surfaces at 3 years · Pregnant women (for preventing dental caries in the primary teeth of their children)

Fluoride supplementation (tablets, drops, lozenges or chewing gum) showed no clear difference in decayed primary surfaces at 3 years compared with placebo or no treatment; GRADE not reported.

2 findings from 1 review

Intervention not reported

Elimination of all clinical signs of ocular surface inflammation ('complete success'), preferably measured by a composite grading system, at three months (± one month) after start of treatment · children with blepharokeratoconjunctivitis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Improvement of clinical signs of ocular surface inflammation ('partial success'), preferably measured by a composite grading system, at three months (± one month) after start of treatment · children with blepharokeratoconjunctivitis
1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Decayed or filled primary tooth surfaces at 3 years · Pregnant women (for preventing dental caries in the primary teeth of their children)

It is very uncertain whether fluoride supplementation (tablets, drops, lozenges or chewing gum) changes decayed or filled primary tooth surfaces at 3 years compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Decayed or filled primary tooth surfaces at 5 years · Pregnant women (for preventing dental caries in the primary teeth of their children)

It is very uncertain whether fluoride supplementation (tablets, drops, lozenges or chewing gum) changes decayed or filled primary tooth surfaces at 5 years compared with placebo or no treatment (very low certainty).

1 finding from 1 review

ART using resin-modified glass ionomer cement (RM-GIC) vs Conventional treatment using RM-GIC

Restoration failure (permanent, mature dentition; root surfaces) · Older adults with root caries in permanent (mature) teeth (mean age 75 years)

It is very uncertain whether ART using resin-modified glass ionomer cement (RM-GIC) changes restoration failure (permanent, mature dentition; root surfaces) compared with conventional treatment using RM-GIC (very low certainty).

1 finding from 1 review

Fluoride mouthrinse (any fluoride agent, concentration, volume, frequency or technique; swished and expectorated, not swallowed) vs placebo or no treatment

Dental caries: dmfs increment (primary teeth) · Children and adolescents aged 16 years or less

The review found no eligible studies for this question.

1 finding from 1 review