Grades 3 and 4 adverse events · individuals with moderate or severe COVID‐19
Hyperimmune immunoglobulin from human plasma probably leads to higher adverse events at grades 3 to 4 up to 28 days compared with saline placebo (moderate certainty).
1 finding from 1 review
RR 4.09 [1.39, 12.01]
Studies not reported
Moderate
Serious adverse events up to day 28 (data available only as a composite of serious adverse events or death up to day 28) · individuals with moderate or severe COVID‐19
Hyperimmune immunoglobulin from human plasma showed no clear difference in serious adverse events up to day 28 (data available only as a… compared with saline placebo (low certainty).
1 finding from 1 review
RR 0.72 [0.45, 1.14]
Studies not reported
Low
All‐cause mortality (by day 28) · individuals with moderate or severe COVID‐19
RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies… showed no clear difference in all‐cause mortality (by day 28) compared with saline placebo (low certainty).
1 finding from 1 review
Worsening of clinical status (expressed as new need for IMV, admission to ICU, or death by day 28) · individuals with moderate or severe COVID‐19
RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies… showed no clear difference in worsening of clinical status (expressed as new need for IMV,… compared with saline placebo (low certainty).
1 finding from 1 review
Reduction in wound size · people with acute and chronic wounds
It is very uncertain whether tap water changes reduction in wound size compared with normal saline (very low certainty).
1 finding from 1 review
Healing rate · people with acute and chronic wounds
1 finding from 1 review
Cost analysis · people with acute and chronic wounds
1 finding from 1 review
Pain · people with acute and chronic wounds
The review found no eligible studies for this question.
1 finding from 1 review
Patient satisfaction · people with acute and chronic wounds
1 finding from 1 review
Infection · people with fractures
It is very uncertain whether distilled water changes infection compared with normal saline (very low certainty).
1 finding from 1 review
Number of wounds healed · people with fractures
1 finding from 1 review
Reduction in wound size · people with fractures
The review found no eligible studies for this question.
1 finding from 1 review
Healing rate · people with fractures
The review found no eligible studies for this question.
1 finding from 1 review
Cost analysis · people with fractures
The review found no eligible studies for this question.
1 finding from 1 review
Pain · people with fractures
The review found no eligible studies for this question.
1 finding from 1 review
Patient satisfaction · people with fractures
The review found no eligible studies for this question.
1 finding from 1 review
Infection · people with fractures
It is very uncertain whether cooled boiled water changes infection compared with normal saline (very low certainty).
1 finding from 1 review
Wound healing · people with fractures
The review found no eligible studies for this question.
1 finding from 1 review
Reduction in wound size · people with fractures
The review found no eligible studies for this question.
1 finding from 1 review
Healing rate · people with fractures
The review found no eligible studies for this question.
1 finding from 1 review