Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

364 questions · 388 findings · 28 reviews · Headline outcomes only

No studies found 15 · 3.9%GRADE not reported 20 · 5.2%Very low 133 · 34.3%Low 161 · 41.5%Moderate 58 · 14.9%High 1 · 0.3%

Psychotherapy as an adjunct to usual care vs usual care

Depressive symptoms · treatment‐resistant depression in adults

Psychotherapy as an adjunct to usual care showed no clear difference in self‐reported depressive symptoms short term (up to 6 months) ‐ BDI… compared with usual care alone (moderate certainty).

8 findings from 1 review
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Psychotherapy as an adjunct to usual care vs usual care

Dropout · treatment‐resistant depression in adults

Psychotherapy as an adjunct to usual care showed no clear difference in dropout medium term (7 to 12 months)* compared with usual care alone (moderate certainty).

2 findings from 1 review

Psychotherapy as an adjunct to usual care vs usual care

Response (50% reduction in BDI) medium term (7 to 12 months)* · treatment‐resistant depression in adults

Psychotherapy as an adjunct to usual care may leads to higher response (50% reduction in BDI) medium term (7 to 12 months)* compared with usual care alone (low certainty).

1 finding from 1 review

Psychotherapy as an adjunct to usual care vs usual care

Response (50% reduction in BDI) long term (longer than 12 months)* · treatment‐resistant depression in adults

Psychotherapy as an adjunct to usual care may leads to higher response (50% reduction in BDI) long term (longer than 12 months)* compared with usual care alone (low certainty).

1 finding from 1 review

Psychotherapy as an adjunct to usual care vs usual care

Remission · treatment‐resistant depression in adults

Psychotherapy as an adjunct to usual care probably leads to higher remission (< 7 on HAMD or < 10 on BDI) medium term (7 to 12 months)* compared with usual care alone (moderate certainty).

2 findings from 1 review

Psychotherapy as an adjunct to usual care vs usual care

> 50% reduction in depressive symptoms · treatment‐resistant depression in adults

Psychotherapy as an adjunct to usual care may leads to higher response (50% reduction in depressive symptoms from baseline) short… compared with usual care alone (low certainty).

1 finding from 1 review