Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

805 questions · 838 findings · 55 reviews · Wounds

No studies found 354 · 42.2%GRADE not reported 38 · 4.5%Very low 283 · 33.8%Low 132 · 15.8%Moderate 27 · 3.2%High 4 · 0.5%

Negative pressure wound therapy vs standard dressing

Mortality (proportion of participants dying in each group at · adult patients with surgical wounds healing by primary closure

Negative pressure wound therapy showed no clear difference in mortality (proportion of participants dying in each group at compared with standard dressing (low certainty).

1 finding from 1 review

Negative pressure wound therapy vs standard dressing

Surgical site infection · adult patients with surgical wounds healing by primary closure

Negative pressure wound therapy probably leads to lower surgical site infection (proportion of participants in each group… compared with standard dressing (moderate certainty).

1 finding from 1 review

Negative pressure wound therapy vs standard dressing

Wound dehiscence · adult patients with surgical wounds healing by primary closure

Negative pressure wound therapy showed no clear difference in dehiscence (proportion of participants in each group with wound… compared with standard dressing (moderate certainty).

1 finding from 1 review

Negative pressure wound therapy vs standard dressing

Seroma (proportion of participants in each group with seroma; · adult patients with surgical wounds healing by primary closure

Negative pressure wound therapy showed no clear difference in seroma (proportion of participants in each group with seroma; compared with standard dressing (low certainty).

1 finding from 1 review

Negative pressure wound therapy vs standard dressing

Haematoma (proportion of participants in each group with haematoma; · adult patients with surgical wounds healing by primary closure

It is very uncertain whether negative pressure wound therapy changes haematoma (proportion of participants in each group with haematoma; compared with standard dressing (very low certainty).

1 finding from 1 review

Negative pressure wound therapy vs standard dressing

Skin blisters (proportion of participants in each group with at least one skin blister; · adult patients with surgical wounds healing by primary closure

Negative pressure wound therapy may leads to higher skin blisters (proportion of participants in each group with at… compared with standard dressing (low certainty).

1 finding from 1 review

Pressure‐garment therapy (PGT) plus silicone vs no treatment/lanolin

Scar improvement (POSAS) (0–10, higher score = more severe scarring) · people with burn wounds likely to develop hypertrophic scarring
2 findings from 1 review

Pressure‐garment therapy (PGT) plus silicone vs silicone

Scar improvement (POSAS) (0–10, higher score = more severe scarring) · people with burn wounds likely to develop hypertrophic scarring
2 findings from 1 review