Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

637 questions · 674 findings · 79 reviews · Gut

No studies found 116 · 17.2%GRADE not reported 14 · 2.1%Very low 133 · 19.7%Low 225 · 33.4%Moderate 145 · 21.5%High 41 · 6.1%

Chemotherapy vs placebo, best supportive care (BSC) or no treatment

Overall survival · advanced gastric and oesophago‐gastric junction adenocarcinoma

Chemotherapy probably leads to lower overall survival compared with placebo, best supportive care (BSC) or no treatment (moderate certainty).

1 finding from 1 review

Biological therapy vs placebo, best supportive care (BSC) or no treatment

Any adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

Biological therapy showed no clear difference in any adverse events compared with placebo, best supportive care (BSC) or no treatment (high certainty).

1 finding from 1 review

Chemotherapy vs placebo, best supportive care (BSC) or no treatment

Progression‐free survival · advanced gastric and oesophago‐gastric junction adenocarcinoma

Chemotherapy leads to lower progression‐free survival compared with placebo, best supportive care (BSC) or no treatment (high certainty).

1 finding from 1 review

Chemotherapy vs placebo, best supportive care (BSC) or no treatment

Serious adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

Chemotherapy probably leads to higher serious adverse events compared with placebo, best supportive care (BSC) or no treatment (moderate certainty).

1 finding from 1 review

Chemotherapy vs placebo, best supportive care (BSC) or no treatment

Tumour response · advanced gastric and oesophago‐gastric junction adenocarcinoma

Chemotherapy showed no clear difference in tumour response rate compared with placebo, best supportive care (BSC) or no treatment (low certainty).

1 finding from 1 review

Chemotherapy vs placebo, best supportive care (BSC) or no treatment

Any adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

Chemotherapy showed no clear difference in any adverse events compared with placebo, best supportive care (BSC) or no treatment (high certainty).

1 finding from 1 review

Biological therapy vs placebo, best supportive care (BSC) or no treatment

Progression‐free survival · advanced gastric and oesophago‐gastric junction adenocarcinoma

Biological therapy probably leads to lower progression‐free survival compared with placebo, best supportive care (BSC) or no treatment (moderate certainty).

1 finding from 1 review

Biological therapy vs placebo, best supportive care (BSC) or no treatment

Serious adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

Biological therapy showed no clear difference in serious adverse events compared with placebo, best supportive care (BSC) or no treatment (low certainty).

1 finding from 1 review

Biological therapy vs placebo, best supportive care (BSC) or no treatment

Tumour response · advanced gastric and oesophago‐gastric junction adenocarcinoma

Biological therapy may leads to higher tumour response rate compared with placebo, best supportive care (BSC) or no treatment (low certainty).

1 finding from 1 review