What do systematic reviews say?

naltrexone vs placebo or no pharmacological treatment

naltrexone showed no clear difference in abstinence at compared with placebo or no pharmacological treatments; GRADE not reported.

• Oral naltrexone maintenance treatment for opioid dependence 2011 · Cochrane Headline outcomes only
  RR 1.28 [0.8, 2.05]
  3 studies · 116 participants
  GRADE not reported

naltrexone vs placebo or no pharmacological treatment

naltrexone showed no clear difference in side effects compared with placebo or no pharmacological treatments; GRADE not reported.

• Oral naltrexone maintenance treatment for opioid dependence 2011 · Cochrane Headline outcomes only
  RR 1.29 [0.54, 3.11]
  4 studies · 159 participants
  GRADE not reported

Antidepressants vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 225 participants
  Very low

Opioid antagonists vs placebo

The review found no eligible studies for this question.

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Opioid antagonists vs placebo

The review found no eligible studies for this question.

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Opioid antagonists vs placebo

The review found no eligible studies for this question.

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Opioid antagonists vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 77 participants
  Low

Opioid antagonists vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 77 participants
  Low

Opioid antagonists vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 77 participants
  Low

Opioid antagonists vs placebo

It is very uncertain whether opioid antagonists changes responder status compared with placebo (very low certainty).

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  RR 1.65 [0.86, 3.14]
  4 studies · 562 participants
  Very low

Mood stabilisers vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 71 participants
  Very low

Mood stabilisers vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 29 participants
  Very low

Mood stabilisers vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 29 participants
  Very low

Antidepressants vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 144 participants
  Low

Mood stabilisers vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 29 participants
  Very low

Mood stabilisers vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 71 participants
  Very low

Mood stabilisers vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 71 participants
  Very low

Mood stabilisers vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 42 participants
  Very low

Mood stabilisers vs placebo

It is very uncertain whether mood stabilisers changes responder status compared with placebo (very low certainty).

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  RR 2.69 [1.14, 6.32]
  1 study · 40 participants
  Very low

Atypical antipsychotics vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 63 participants
  Very low