Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

870 questions · 912 findings · 85 reviews · Airways

No studies found 65 · 7.1%GRADE not reported 34 · 3.7%Very low 115 · 12.6%Low 273 · 29.9%Moderate 330 · 36.2%High 95 · 10.4%

Nebulised magnesium sulfate + standard care vs placebo + standard care

Proportion of people with hospital admissions (from the emergency room) · acute exacerbations of chronic obstructive pulmonary disease

It is very uncertain whether nebulised magnesium sulfate + standard care changes proportion of people with hospital admissions (from the emergency… compared with placebo + standard care (very low certainty).

1 finding from 1 review

Nebulised magnesium sulfate + standard care vs placebo + standard care

Incidence of admissions to the ICU · acute exacerbations of chronic obstructive pulmonary disease

It is very uncertain whether nebulised magnesium sulfate + standard care changes proportion of people requiring ICU admission compared with placebo + standard care (very low certainty).

1 finding from 1 review

Endothelin receptor antagonists vs placebo

Proportion of participants with improved functional class mean duration of study 16.8 weeks · pulmonary arterial hypertension

Endothelin receptor antagonists probably leads to higher proportion of participants with improved functional class mean… compared with placebo (moderate certainty).

1 finding from 1 review

Integrated disease management interventions vs usual care

Respiratory‐related hospital admissions · patients with chronic obstructive pulmonary disease

Integrated disease management interventions leads to lower respiratory‐related hospital admissions compared with usual care (high certainty).

1 finding from 1 review

Remote monitoring plus usual care vs usual care

Mortality (all‐cause) · patients with chronic obstructive pulmonary disease

It is very uncertain whether remote monitoring plus usual care changes mortality (all‐cause) compared with usual care (very low certainty).

1 finding from 1 review

Remote monitoring vs usual care

Exacerbations (number of people experiencing ≥ 1 exacerbations) · patients with chronic obstructive pulmonary disease

It is very uncertain whether remote monitoring changes number of people experiencing 1 or more exacerbations compared with usual care (very low certainty).

1 finding from 1 review