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What do systematic reviews say?

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Evidence found and GRADE certainty

407 questions · 424 findings · 34 reviews · Headline outcomes only

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No studies found 65 · 15.3%GRADE not reported 36 · 8.5%Very low 86 · 20.3%Low 133 · 31.4%Moderate 88 · 20.8%High 16 · 3.8%

Summary of findings table ‐ Convalescent plasma vs placebo or usual care

Admission to hospital or death within 28 days · outpatients withmild disease

Summary of findings table ‐ Convalescent plasma showed no clear difference in admission to hospital or death within 28 days compared with placebo or standard care alone (low certainty).

1 finding from 1 review

Summary of findings table ‐ Convalescent plasma vs placebo or usual care

Time to symptom resolution · outpatients withmild disease

Summary of findings table ‐ Convalescent plasma showed no clear difference in time to symptom resolution (absolute effect calculated for day 12) compared with placebo or standard care alone (low certainty).

1 finding from 1 review

Summary of findings table ‐ Convalescent plasma vs standard plasma

All‐cause mortality at up to day 28 · outpatients withmild disease

It is very uncertain whether summary of findings table ‐ Convalescent plasma changes all‐cause mortality at up to day 28 compared with standard plasma (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Convalescent plasma vs standard plasma

Admission to hospital or death within 28 days · outpatients withmild disease

Summary of findings table ‐ Convalescent plasma probably leads to lower admission to hospital or death within 28 days compared with standard plasma (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Convalescent plasma vs standard plasma

Resolution of symptoms · outpatients withmild disease

Summary of findings table ‐ Convalescent plasma showed no clear difference in symptom resolution‐ all initial symptoms resolved compared with standard plasma (low certainty).

2 findings from 1 review