Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

610 questions · 675 findings · 57 reviews · Oral Health

No studies found 105 · 15.6%GRADE not reported 429 · 63.6%Very low 102 · 15.1%Low 31 · 4.6%Moderate 8 · 1.2%High 0 · 0%

Primary closure of the extraction socket with a mucoperiosteal flap vs Application of platelet-rich fibrin (PRF) without primary closure

Complications and side effects · People on antiresorptive treatment undergoing tooth extraction (at risk of MRONJ)
1 finding from 1 review

Combined HBO and perioperative antibiotics prior to dental implant therapy vs antibiotics alone

Adverse effects (including quality of life) · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)
1 finding from 1 review

Combined HBO and perioperative antibiotics prior to dental implant therapy vs antibiotics alone

Incidence of ORN · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)

It is very uncertain whether combined HBO and perioperative antibiotics prior to dental implant… changes incidence of ORN compared with antibiotics alone prior to dental implant therapy (very low certainty).

1 finding from 1 review

Ultrasound during vertical distraction osteogenesis vs Placebo (no ultrasound) during vertical distraction

Distraction distance (bone gain, mm) · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Ultrasound during vertical distraction osteogenesis showed no clear difference in distraction distance (bone gain, mm) compared with placebo (no ultrasound) during vertical distraction; GRADE not reported.

1 finding from 1 review

Vertical GBR with non-resorbable titanium-reinforced barriers vs Vertical GBR with resorbable barriers supported by osteosynthesis plates

Perimplant bone loss · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical GBR with non-resorbable titanium-reinforced barriers showed no clear difference in perimplant bone loss (3 years) compared with vertical GBR with resorbable barriers supported by osteosynthesis…; GRADE not reported.

1 finding from 1 review

Vertical GBR with non-resorbable titanium-reinforced barriers vs Vertical GBR with resorbable barriers supported by osteosynthesis plates

Vertical bone gain · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical GBR with non-resorbable titanium-reinforced barriers showed no clear difference in vertical bone gain compared with vertical GBR with resorbable barriers supported by osteosynthesis…; GRADE not reported.

1 finding from 1 review

Honey (Manuka, topical) vs Chlorhexidine rinse (0.2%)

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Honey (Manuka, topical) showed no clear difference in presence of dry socket compared with chlorhexidine rinse (0.2%); GRADE not reported.

1 finding from 1 review

Single full-coverage metal-ceramic crown over composite core and post vs Direct adhesive composite restoration with post (conventional filling, no crown)

Cost of the intervention · People with a permanent tooth that has undergone endodontic (root canal) treatment

The review found no eligible studies for this question.

1 finding from 1 review

Jaw opening exercises alone vs Ultrasound plus jaw opening exercises

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether jaw opening exercises alone changes maximal mouth opening (interincisal distance) compared with ultrasound plus jaw opening exercises (very low certainty).

1 finding from 1 review

Intralesional betamethasone vs placebo

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
  • Goel 2015 (3-arm: intralesional betamethasone vs lycopene vs placebo, 90 per arm): appeared to show increased interincisal distance in both intervention groups vs placebo, but only between-group differences with no…
    1 study · 180 participants
    GRADE not reported

Intralesional triamcinolone vs Intralesional salvianolic acid B

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether intralesional triamcinolone changes maximal mouth opening (interincisal distance) compared with intralesional salvianolic acid B (very low certainty).

1 finding from 1 review

Trazodone vs placebo

Change in taste · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

The review found no eligible studies for this question.

1 finding from 1 review

Trazodone vs placebo

Change in feeling of dryness · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

The review found no eligible studies for this question.

1 finding from 1 review