Findings

What do systematic reviews say?

317 questions · 341 findings · 38 reviews · Vascular

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No studies found 55 · 16.1%GRADE not reported 32 · 9.4%Very low 58 · 17%Low 117 · 34.3%Moderate 57 · 16.7%High 22 · 6.5%

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

30‐Day mortality · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Vessel patency (up to 30 days) · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Duration of thrombolysis (to end of treatment) · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Stroke · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Major bleeding · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Intervention not reported

30‐Day amputation‐free survival · patients with less than 42 days' lower limb ischaemia

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 70 participants
GRADE not reported

Intervention not reported

Amputation ( · patients with less than 42 days' lower limb ischaemia

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 70 participants
GRADE not reported

Intervention not reported

30‐Day mortality · patients with less than 42 days' lower limb ischaemia

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 70 participants
GRADE not reported

Intervention not reported

Vessel patency ( · patients with less than 42 days' lower limb ischaemia

It is very uncertain whether the intervention changes vessel patency ( (very low certainty).

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
OR 1.2 [0.39, 3.69]
1 study · 70 participants
Very low

Intervention not reported

Duration of thrombolysis ( · patients with less than 42 days' lower limb ischaemia

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 70 participants
Low

Intervention not reported

CVA ( · patients with less than 42 days' lower limb ischaemia

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 70 participants
Low

Intervention not reported

Major bleeding ( · patients with less than 42 days' lower limb ischaemia

It is very uncertain whether the intervention changes major bleeding ( (very low certainty).

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
OR 0.25 [0.01, 4.9]
1 study · 70 participants
Very low

High‐dose vs low‐dose regimens of thrombolytic agents

30‐Day amputation‐free survival · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 302 participants
Very low

High‐dose vs low‐dose regimens of thrombolytic agents

Amputation · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 302 participants
Very low

Intervention not reported

Proximal DVT · Patients hospitalised following acute myocardial infarction

The review found no eligible studies for this question.

1 finding from 1 review

Graduated compression stockings for prevention of deep vein thrombosis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Pulmonary embolism · Patients hospitalised following acute myocardial infarction

The review found no eligible studies for this question.

1 finding from 1 review

Graduated compression stockings for prevention of deep vein thrombosis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Adverse effects and complications · Patients hospitalised following acute myocardial infarction

The review found no eligible studies for this question.

1 finding from 1 review

Graduated compression stockings for prevention of deep vein thrombosis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Deep vein thrombosis (DVT) · Patients hospitalised following acute myocardial infarction

The intervention may leads to lower deep vein thrombosis (DVT) (low certainty).

1 finding from 1 review

Graduated compression stockings for prevention of deep vein thrombosis 2018 · Cochrane Headline outcomes only
OR 0.12 [0.03, 0.51]
Studies not reported
Low

PTFE vs PTFE with vein cuff

Primary patency ( · people with peripheral vascular disease requiring below‐knee femoro‐popliteal bypass surgery

It is very uncertain whether PTFE changes primary patency (24 months) compared with PTFE with vein cuff (very low certainty).

2 findings from 1 review

Graft type for femoro‐popliteal bypass surgery 2018 · Cochrane Headline outcomes only
OR 1.08 [0.58, 2.01]
Studies not reported
Very low
Graft type for femoro‐popliteal bypass surgery 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

PTFE vs PTFE with vein cuff

Secondary patency (24 months) · people with peripheral vascular disease requiring below‐knee femoro‐popliteal bypass surgery

It is very uncertain whether PTFE changes secondary patency (24 months) compared with PTFE with vein cuff (very low certainty).

1 finding from 1 review

Graft type for femoro‐popliteal bypass surgery 2018 · Cochrane Headline outcomes only
OR 1.22 [0.67, 2.23]
Studies not reported
Very low