What do systematic reviews say?

Glucosamine sulfate (oral) vs ibuprofen

Glucosamine sulfate (oral) showed no clear difference in maximum voluntary jaw opening (mm), change from baseline compared with ibuprofen (oral); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  90 days
  MD 3.08 [-0.97, 7.13]
  1 study · 45 participants
  GRADE not reported

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Intra-articular injection of sodium hyaluronate showed no clear difference in complications (adverse effects) compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
  RR 1.20 [0.44, 3.30]
  1 study · 40 participants
  GRADE not reported

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Intra-articular injection of sodium hyaluronate led to lower presence of TMJ sounds compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  14 days
  RR 0.59 [0.37, 0.95]
  1 study · 40 participants
  GRADE not reported

Glucosamine sulfate (oral) vs ibuprofen

Glucosamine sulfate (oral) showed no clear difference in extraoral masticatory muscle tenderness (number of tender sites),… compared with ibuprofen (oral); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  90 days
  MD 0.38 [-2.30, 3.06]
  1 study · 45 participants
  GRADE not reported

Laser therapy

The review found no eligible studies for this question.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
  The review noted the noticeable absence of evidence for laser therapy; no eligible RCT evaluated it (Discussion).
  0 studies
  No studies found

Oral diclofenac sodium (NSAID) vs splint

Diclofenac sodium (oral NSAID) showed no clear difference in complications (adverse effects) compared with occlusal splint therapy; GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
  RR 1.07 [0.50, 2.28]
  1 study · 29 participants
  GRADE not reported

Glucosamine sulfate (oral) vs ibuprofen

Glucosamine sulfate (oral) showed no clear difference in reported pain (mm on VAS), change from baseline compared with ibuprofen (oral); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  90 days
  MD -4.57 [-9.91, 0.77]
  1 study · 45 participants
  GRADE not reported

Glucosamine sulfate (oral) vs ibuprofen

Glucosamine sulfate (oral) showed no clear difference in brief Pain Inventory (BPI) - pain intensity, change from baseline compared with ibuprofen (oral); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  90 days
  MD -2.69 [-7.38, 2.00]
  1 study · 45 participants
  GRADE not reported

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Intra-articular injection of sodium hyaluronate led to lower pain on palpation of the affected/contralateral TMJ and masticatory… compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  14 days to 6 months
  Pain on palpation of the affected and contralateral TMJ and masticatory muscles presented similar frequencies regardless of the time (Analyses 1.4-1.12); no statistically significant differences reported. Point…
  1 study · 40 participants
  GRADE not reported

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Intra-articular injection of sodium hyaluronate showed no clear difference in extent of mandibular movement (maximum jaw opening, lateral and… compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  14 days to 6 months
  None of the mean differences between interventions for the measures of jaw movements (maximum jaw opening, lateral movement to affected side, contralateral movement, jaw protrusion; Analyses 1.16-1.27) showed…
  1 study · 40 participants
  GRADE not reported

Reassurance / behavioral management (control of contributory factors)

The review found no eligible studies for this question.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
  The review noted the noticeable absence of evidence for reassurance among interventions for TMJ OA; no eligible RCT evaluated it (Discussion).
  0 studies
  No studies found

Glucosamine sulfate (oral) vs ibuprofen

Glucosamine sulfate (oral) showed no clear difference in pain-free maximum jaw opening (mm), change from baseline compared with ibuprofen (oral); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  90 days
  MD 1.75 [-4.10, 7.60]
  1 study · 45 participants
  GRADE not reported

Arthrocentesis

The review found no eligible studies for this question.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
  No study evaluated arthrocentesis for TMJ OA, which should be explored in future trials (Research recommendations Table 1).
  0 studies
  No studies found

Iontophoretically applied corticosteroids

The review found no eligible studies for this question.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
  The review noted the noticeable absence of evidence for iontophoretically applied corticosteroids; no eligible RCT evaluated it (Discussion).
  0 studies
  No studies found

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Intra-articular injection of sodium hyaluronate led to lower reported pain (mm on VAS) compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  6 months
  MD -17.00 [-32.60, -1.40]
  1 study · 40 participants
  GRADE not reported

Glucosamine sulfate (oral) vs ibuprofen

Glucosamine sulfate (oral) showed no clear difference in brief Pain Inventory (BPI) - pain interference, change from baseline compared with ibuprofen (oral); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  90 days
  MD -6.74 [-14.70, 1.22]
  1 study · 45 participants
  GRADE not reported

Physiotherapy modalities (physiotherapy, short-wave diathermy, ultrasound)

The review found no eligible studies for this question.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
  The review noted the noticeable absence of evidence for physiotherapy, short-wave diathermy and ultrasound; no eligible RCT evaluated these (Discussion).
  0 studies
  No studies found

Oral diclofenac sodium (NSAID) vs splint

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
  The study reports morphological changes assessed by CT for the entire sample without distinction of group, so extraction was not possible.
  1 study
  GRADE not reported

Oral diclofenac sodium (NSAID) vs splint

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  1 week and 3 months
  Data for pain on movement or pain on palpation of the affected TMJ (both at 1 week and 3 months) could not be extracted, as they are described as percentages of an unclear total number. Narratively, diclofenac sodium…
  1 study
  GRADE not reported

Open TMJ surgery (arthroplasty / total joint replacement)

The review found no eligible studies for this question.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
  No study evaluated open surgery for TMJ OA, which should be explored in future trials (Research recommendations Table 1; Discussion).
  0 studies
  No studies found