Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

598 questions · 645 findings · 40 reviews

No studies found 111 · 17.2%GRADE not reported 91 · 14.1%Very low 168 · 26%Low 146 · 22.6%Moderate 107 · 16.6%High 22 · 3.4%

Two infusions of natalizumab (300 mg or 3 mg/kg) vs placebo

Failure to induce clinical response (Panaccione 2010) CDAI ‐ (≥100 point reduction) · Patients with active Crohn's disease

Two infusions of natalizumab (300 mg or 3 mg/kg) showed no clear difference in failure to induce clinical response at 6 weeks compared with placebo (low certainty).

1 finding from 1 review

Two infusions of natalizumab (6 mg/kg) vs placebo

Failure to induce remission at 6 weeks · Patients with active Crohn's disease

Two infusions of natalizumab (6 mg/kg) showed no clear difference in failure to induce remission at 6 weeks compared with placebo (moderate certainty).

2 findings from 1 review

Two infusions of natalizumab (6 mg/kg) vs placebo

Failure to induce clinical response (Panaccione 2010) CDAI ‐ (≥100 point reduction) · Patients with active Crohn's disease

Two infusions of natalizumab (6 mg/kg) showed no clear difference in failure to induce clinical response at 6 weeks compared with placebo (moderate certainty).

2 findings from 1 review

Three infusions of natalizumab (300 mg) vs placebo

Failure to induce remission at 10 weeks · Patients with active Crohn's disease

Three infusions of natalizumab (300 mg) showed no clear difference in failure to induce remission at 10 weeks compared with placebo (high certainty).

2 findings from 1 review

Three infusions of natalizumab (300 mg) vs placebo

Failure to induce clinical response at end of study · Patients with active Crohn's disease

Three infusions of natalizumab (300 mg) showed no clear difference in failure to induce clinical response at 10 weeks compared with placebo (high certainty).

2 findings from 1 review