Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,187 questions · 1,233 findings · 137 reviews

No studies found 190 · 15.4%GRADE not reported 57 · 4.6%Very low 241 · 19.5%Low 323 · 26.2%Moderate 315 · 25.5%High 107 · 8.7%

Systemic corticosteroids vs placebo

Pain (dichotomous) Pain improved (definitions varied)c · people with radicular low back pain (not due to spinal stenosis)

Systemic corticosteroids showed no clear difference in pain (dichotomous) Pain improved (definitions varied)c compared with placebo (moderate certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo

Function (dichotomous) Function improved (definitions varied)f · people with radicular low back pain (not due to spinal stenosis)

Systemic corticosteroids probably leads to higher function (dichotomous) Function improved (definitions varied)f compared with placebo (moderate certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo

Mortality or serious adverse events requiring hospital admission · people with radicular low back pain (not due to spinal stenosis)

It is very uncertain whether systemic corticosteroids changes participants who experienced a serious adverse event Adverse event… compared with placebo (very low certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo

Participants with hyperglycemia "Transient hyperglycemia" or blood sugar increase ≥ 50 mg/dL · people with radicular low back pain (not due to spinal stenosis)

Systemic corticosteroids showed no clear difference in participants with hyperglycemia "Transient hyperglycemia" or blood… compared with placebo (low certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo

Dyspnea · adults with cancer‐related breathlessness (dyspnoea)
2 findings from 1 review