The review found no eligible studies for this question.
Cytarabine plus high‐dose methotrexate probably leads to higher infections (grade 3 to 4) compared with high‐dose methotrexate alone (moderate certainty).
The intervention showed no clear difference in mortality (calculated instead of overall survival) (moderate certainty).
The intervention probably leads to lower relapse, progression or death (calculated instead of PFS)… (moderate certainty).
The intervention showed no clear difference in infection‐ related mortality (low certainty).
The intervention showed no clear difference in second cancer‐ related mortality (low certainty).
The intervention showed no clear difference in cardiac disease‐ related mortality (low certainty).
The review found no eligible studies for this question.
The intervention probably leads to lower mortality sensitivity analysis (calculated instead of overall… (moderate certainty).
The intervention probably leads to lower relapse, progression or death (calculated instead of PFS) (moderate certainty).
The intervention showed no clear difference in infection‐ related mortality (low certainty).
The intervention showed no clear difference in second cancer‐ related mortality (low certainty).
The intervention showed no clear difference in cardiac disease‐ related mortality (low certainty).
The intervention showed no clear difference in complete response rate (low certainty).
The intervention may leads to higher mortality (calculated instead of overall survival) (low certainty).
The intervention showed no clear difference in relapse, progression or death (calculated instead of PFS) (low certainty).
IRI with fluoropyrimidines showed no clear difference in overall survival (Death) compared with single agent IRI (low certainty).
IRI with fluoropyrimidines probably leads to lower progression‐free survival (Disease progression) compared with single agent IRI (moderate certainty).
IRI with fluoropyrimidines probably leads to lower grade 3/4 diarrhea compared with single agent IRI (moderate certainty).
IRI with fluoropyrimidines showed no clear difference in grade 3/4 nausea compared with single agent IRI (low certainty).