Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,036 questions · 1,100 findings · 261 reviews

No studies found 160 · 14.5%GRADE not reported 188 · 17.1%Very low 270 · 24.5%Low 303 · 27.5%Moderate 139 · 12.6%High 40 · 3.6%

Sealant/coating agent WITHOUT fluoride release applied to teeth with fixed appliances vs No sealant (control/no treatment)

Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances

Among non-fluoride sealants, WSL initiation was significantly reduced versus no sealant (RR 0.69); subgroup not separately GRADE-rated.

1 finding from 1 review

Compomer (polyacid-modified composite, fluoride-releasing) for bonding brackets vs Compomer bonding agent without fluoride release

Initiation of white spot lesions (WSL), visual-tactile assessment · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)

Fluoride-releasing compomer bonding agent did not show a statistically significant reduction in new white spot lesions versus non-fluoride compomer bonding agent (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) vs no treatment/placebo

Symptomatic thromboembolic events ( · women giving birth by elective or emergency caesarean (elective only (1 trial), emergency or elective (4 trials))

It is very uncertain whether peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) changes symptomatic thromboembolic events (timing of assessment unclear,… compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) vs no treatment/placebo

Symptomatic PE · women giving birth by elective or emergency caesarean (elective only (1 trial), emergency or elective (4 trials))

It is very uncertain whether peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) changes symptomatic PE (timing of assessment unclear, within 6 weeks… compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis (caesarean): LMWH vs UFH

Symptomatic thromboembolic events ( · women giving birth by elective or emergency caesarean (elective or emergency (1 trial), elective cesarean only (1 trial),…

It is very uncertain whether peripartum/postnatal prophylaxis (caesarean): LMWH changes symptomatic thromboembolic events (timing of assessment unclear,… compared with UFH (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis (caesarean): LMWH vs UFH

Symptomatic DVT · women giving birth by elective or emergency caesarean (elective or emergency (1 trial), elective cesarean only (1 trial),…

It is very uncertain whether peripartum/postnatal prophylaxis (caesarean): LMWH changes symptomatic DVT (timing of assessment unclear, within 6 weeks… compared with UFH (very low certainty).

1 finding from 1 review

High‐dose vs low‐dose colchicine

Participant global assessment of treatment success: proportion with 50% or greater decrease in pain score from baseline ‐ 32 to 36 hours · acute gout

High‐dose showed no clear difference in participant global assessment of treatment success: proportion with… compared with low‐dose colchicine (low certainty).

1 finding from 1 review

Low‐dose colchicine vs placebo

Participant global assessment of treatment success: proportion with 50% or greater decrease in pain score from baseline ‐ 32 to 36 hours · acute gout

Low‐dose colchicine may leads to higher participant global assessment of treatment success: proportion with… compared with placebo (low certainty).

1 finding from 1 review

Low‐dose colchicine vs NSAIDs

Global assessment of treatment success · acute gout

Low‐dose colchicine showed no clear difference in participant global assessment of treatment success: Completely… compared with NSAIDs (low certainty).

1 finding from 1 review

High‐dose colchicine vs placebo

Participant global assessment of treatment success: proportion with 50% or greater decrease in pain score from baseline ‐ 32 to 36 hours · acute gout

High‐dose colchicine may leads to higher participant global assessment of treatment success: proportion with… compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Disease progressionAssessed by: dilated assessment of the vertical C/D ratio using a 78 D lens · adults with PAC or PACG, and previous PI
1 finding from 1 review

Surgery for Bell's palsy vs medical treatment (oral prednisolone) or no treatment

Complications and side effects · Bell's palsy

It is very uncertain whether surgery for Bell's palsy changes side effects and complications of treatmentMeasured by clinical… compared with medical treatment (oral prednisolone) or no treatment (very low certainty).

1 finding from 1 review

Lay health worker‐led psychosocial interventions vs enhanced usual care

Functional impairment · women with perinatal depression

Lay health worker‐led psychosocial interventions showed no clear difference in functional impairment ‐ intermediate term (1 to 6 months post… compared with enhanced usual care (low certainty).

1 finding from 1 review

Lay health worker‐ vs specialist‐led care

Caregiver burden · people with severe mental disorders

Lay health worker‐ showed no clear difference in caregiver burden symptom severity ‐ immediately post intervention… compared with specialist‐led care (low certainty).

1 finding from 1 review