Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

234 questions · 320 findings · 14 reviews · All outcomes

No studies found 82 · 25.6%GRADE not reported 176 · 55%Very low 54 · 16.9%Low 5 · 1.6%Moderate 3 · 0.9%High 0 · 0%

Azithromycin + SRP vs SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

It is very uncertain whether azithromycin + SRP changes adverse events compared with SRP (very low certainty).

1 finding from 1 review

Amoxicillin + metronidazole + SRP vs SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

It is very uncertain whether amoxicillin + metronidazole + SRP changes adverse events compared with SRP (very low certainty).

1 finding from 1 review

Levofloxacin + SRP vs SRP

Clinical attachment level (CAL) · Adults with chronic periodontitis

Levofloxacin + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.

2 findings from 1 review

Doxycycline + SRP vs Amoxicillin + metronidazole + SRP

Adverse events · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in adverse events compared with amoxicillin + metronidazole + SRP; GRADE not reported.

1 finding from 1 review

Tetracycline + SRP vs SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

The review found no eligible studies for this question.

2 findings from 1 review