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Topical ointment or cream showed no clear difference in invasive infectionuntil hospital discharge compared with oil (low certainty).
Topical ointment or cream may leads to lower mortality until hospital discharge (or latest reported) compared with oil (low certainty).
Slow showed no clear difference in necrotising enterocolitis before hospital discharge compared with faster rates of enteral feed advancement (moderate certainty).
Slow showed no clear difference in mortality before hospital discharge compared with faster rates of enteral feed advancement (moderate certainty).
Slow may leads to higher feed intolerance before hospital discharge compared with faster rates of enteral feed advancement (low certainty).
Slow showed no clear difference in invasive infection before hospital discharge compared with faster rates of enteral feed advancement (low certainty).
It is very uncertain whether prophylactic or very early CPAP changes failed treatment defined as recurrent apnoea, hypoxia, hypercarbia… compared with supportive care (very low certainty).
Prophylactic CPAP probably leads to lower combined outcome of death and bronchopulmonary dysplasia defined as… compared with mechanical ventilation (moderate certainty).
Prophylactic CPAP probably leads to lower failed treatment defined as the need for mechanical ventilation compared with mechanical ventilation (moderate certainty).
Prophylactic CPAP showed no clear difference in pulmonary air leak defined as pneumothorax compared with mechanical ventilation (low certainty).
Prophylactic CPAP showed no clear difference in intraventricular haemorrhage grade 3 or 4 compared with mechanical ventilation (moderate certainty).
Prophylactic CPAP showed no clear difference in neurodevelopmental impairment defined as cerebral palsy,… compared with mechanical ventilation (moderate certainty).
It is very uncertain whether prophylactic CPAP changes bronchopulmonary dysplasia at 28 days compared with very early CPAP (very low certainty).
The review found no eligible studies for this question.
It is very uncertain whether prophylactic CPAP changes death at any time (by 28 days) compared with very early CPAP (very low certainty).
The review found no eligible studies for this question.
Prophylactic or very early CPAP showed no clear difference in bronchopulmonary dysplasia at 36 weeks defined as oxygen dependency… compared with supportive care (moderate certainty).