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Evidence found and GRADE certainty

3,696 questions · 3,815 findings · 855 reviews

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No studies found 573 · 15%GRADE not reported 374 · 9.8%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

Periodontal treatment (scaling and root planing, polishing, or surgery), alone or with oral hygiene counselling, antiseptics, or antimicrobials vs no treatment

Perinatal mortality · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

It is very uncertain whether periodontal treatment (scaling and root planing, polishing, or… changes perinatal mortality (including fetal and neonatal deaths up to the… compared with no treatment (very low certainty).

1 finding from 1 review

GM-CSF vs placebo or no treatment

Number of days of treatment with opioid analgesics · Adults with cancer receiving treatment

Granulocyte-macrophage colony-stimulating factor (GM-CSF) led to lower number of days of treatment with opioid analgesics compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Epidermal growth factor (EGF), oral spray vs placebo

Interruptions to cancer treatment (radiotherapy breaks longer than two days) · Adults with cancer receiving treatment

Epidermal growth factor (EGF), oral spray showed no clear difference in interruptions to cancer treatment (radiotherapy breaks longer than… compared with placebo; GRADE not reported.

1 finding from 1 review

Erythropoietin mouthwash vs placebo

Number of days in hospital · Adults receiving bone marrow/stem cell transplantation after conditioning therapy for haematological cancers

Erythropoietin mouthwash showed no clear difference in number of days in hospital compared with placebo; GRADE not reported.

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Number of days of treatment with opioid analgesics · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in number of days of treatment with opioid analgesics compared with placebo; GRADE not reported.

1 finding from 1 review

Papilla base incision (PBI) vs Complete papilla mobilisation (sulcular incision)

Postoperative pain (VAS 0-100) - 3 days · People requiring retreatment of periapical lesions (failed root canal therapy)

Papilla base incision (PBI) led to lower postoperative pain (VAS 0-100) - 3 days compared with complete papilla mobilisation (sulcular incision); GRADE not reported.

1 finding from 1 review

Monitoring (any means of observation, supervision, keeping under review, measuring or testing at intervals) vs No monitoring

Oral health: Not brushing teeth twice a day · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs usual care

Oral health: Not brushing teeth twice a day · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Mineral trioxide aggregate (MTA) root-end filling vs Intermediate restorative material (IRM)

Prevalence of pain - 1 day · People requiring retreatment of periapical lesions (failed root canal therapy)

Mineral trioxide aggregate (MTA) root-end filling showed no clear difference in prevalence of pain - 1 day compared with intermediate restorative material (IRM) (low certainty).

1 finding from 1 review

Papilla base incision (PBI) vs Complete papilla mobilisation (sulcular incision)

Postoperative pain (VAS 0-100) - 2 days · People requiring retreatment of periapical lesions (failed root canal therapy)

Papilla base incision (PBI) showed no clear difference in postoperative pain (VAS 0-100) - 2 days compared with complete papilla mobilisation (sulcular incision); GRADE not reported.

1 finding from 1 review

Papilla base incision (PBI) vs Complete papilla mobilisation (sulcular incision)

Postoperative pain (VAS 0-100) - 1 day · People requiring retreatment of periapical lesions (failed root canal therapy)

It is very uncertain whether papilla base incision (PBI) changes postoperative pain (VAS 0-100) - 1 day compared with complete papilla mobilisation (sulcular incision) (very low certainty).

1 finding from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Daytime symptom: thirstiness in the morning (questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)

Oral appliance or functional orthopaedic appliance showed no clear difference in daytime symptom: thirstiness in the morning (questionnaire) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Tiredness · Children with obstructive sleep apnoea (aged 15 years or younger)

It is very uncertain whether oral appliance or functional orthopaedic appliance changes daytime symptom: tiredness (Brouillette questionnaire) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Daytime symptom: sleepiness (Brouillette questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)

It is very uncertain whether oral appliance or functional orthopaedic appliance changes daytime symptom: sleepiness (Brouillette questionnaire) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Irritability · Children with obstructive sleep apnoea (aged 15 years or younger)

It is very uncertain whether oral appliance or functional orthopaedic appliance changes daytime symptom: irritability (Brouillette questionnaire) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Daytime symptom: morning headache (Brouillette questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)

It is very uncertain whether oral appliance or functional orthopaedic appliance changes daytime symptom: morning headache (Brouillette questionnaire) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Mineral trioxide aggregate (MTA) root-end filling vs Gutta-percha smoothing (orthograde GP root filling)

Postoperative pain (VAS 0-100) - 1 day · People requiring retreatment of periapical lesions (failed root canal therapy)

Mineral trioxide aggregate (MTA) root-end filling showed no clear difference in postoperative pain (VAS 0-100) - 1 day compared with gutta-percha smoothing (orthograde GP root filling) (low certainty).

1 finding from 1 review