Progression‐free survival · palliative participants with esophageal and GE‐junction carcinoma
Summary of findings table (subcomparison 4): targeted therapy agent… probably leads to lower progression‐free survival compared with control intervention alone (moderate certainty).
1 finding from 1 review
Toxicity · palliative participants with esophageal and GE‐junction carcinoma
It is very uncertain whether summary of findings table (subcomparison 4): targeted therapy agent… changes toxicity compared with control intervention alone (very low certainty).
1 finding from 1 review
Quality of life · palliative participants with esophageal and GE‐junction carcinoma
1 finding from 1 review
Toxicity · palliative participants with esophageal and GE‐junction carcinoma
It is very uncertain whether summary of findings table: chemotherapy or targeted therapy agent(s)… changes toxicity compared with control intervention alone (very low certainty).
1 finding from 1 review
Quality of life · palliative participants with esophageal and GE‐junction carcinoma
1 finding from 1 review
Incidence of clinical tumour lysis syndrome · children with haematological malignancy at risk of tumour lysis syndrome
Summary of findings: urate oxidase showed no clear difference in incidence of clinical tumour lysis syndrome ( compared with allopurinol (low certainty).
1 finding from 1 review
Mortality due to tumour lysis syndrome · children with haematological malignancy at risk of tumour lysis syndrome
Summary of findings: urate oxidase may leads to lower mortality due to tumour lysis syndrome ( compared with allopurinol (low certainty).
1 finding from 1 review
Organ system failure ‐ Renal insufficiency leading to replacement therapy · children with haematological malignancy at risk of tumour lysis syndrome
It is very uncertain whether summary of findings: urate oxidase changes renal failure requiring renal replacement therapy ( compared with allopurinol (very low certainty).
1 finding from 1 review
Serum urate normalisation ‐ not reported · children with haematological malignancy at risk of tumour lysis syndrome
1 finding from 1 review
Percentage reduction in serum uric acid level · children with haematological malignancy at risk of tumour lysis syndrome
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
AUC of serum uric acid level · children with haematological malignancy at risk of tumour lysis syndrome
1 finding from 1 review
Frequency of adverse events ( · children with haematological malignancy at risk of tumour lysis syndrome
Summary of findings: urate oxidase may leads to higher frequency of adverse events ( compared with allopurinol (low certainty).
1 finding from 1 review
Grade ≥ 3 neutropenia/granulocytopenia · Patients treated with palliative intent for inoperable advanced or metastatic colorectal cancer with chemotherapy
Oral may leads to lower grade ≥ 3 neutropenia/granulocytopenia compared with intravenous fluoropyrimidines (low certainty).
1 finding from 1 review
Progression‐free survival · Patients treated with palliative intent for inoperable advanced or metastatic colorectal cancer with chemotherapy
Oral probably leads to higher progression‐free survival compared with intravenous fluoropyrimidines (moderate certainty).
1 finding from 1 review
Overall survival · Patients treated with palliative intent for inoperable advanced or metastatic colorectal cancer with chemotherapy
Oral showed no clear difference in overall survival compared with intravenous fluoropyrimidines (high certainty).
1 finding from 1 review
Grade ≥ 3 diarrhoea · Patients treated with palliative intent for inoperable advanced or metastatic colorectal cancer with chemotherapy
Oral may leads to higher grade ≥ 3 diarrhoea compared with intravenous fluoropyrimidines (low certainty).
1 finding from 1 review
Hand‐foot syndrome (grade ≥ 3) · Patients treated with palliative intent for inoperable advanced or metastatic colorectal cancer with chemotherapy
Oral probably leads to higher grade ≥ 3 hand foot syndrome compared with intravenous fluoropyrimidines (moderate certainty).
1 finding from 1 review
Reoperation · patients with lumbar stenosis
SUMMARY OF FINDINGS FOR DECOMPRESSION leads to lower reoperations Number of patients requiring a revision surgery compared with INTERSPINOUS SPACERS (high certainty).
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients with lumbar stenosis
SUMMARY OF FINDINGS FOR FUSION showed no clear difference in pain Long‐term (≥ 12 months) Pain scores converted to 0 to 100 scale… compared with INTERSPINOUS SPACERS (low certainty).
1 finding from 1 review
Disability Long‐term (≥ 12 months) Disability scores converted to 0 to 100 scale to allow for comparison of different disability scales (RMDQ, ODI, JOA) · patients with lumbar stenosis
SUMMARY OF FINDINGS FOR FUSION may leads to higher disability Long‐term (≥ 12 months) Disability scores converted to 0… compared with INTERSPINOUS SPACERS (low certainty).
1 finding from 1 review