Vertical bone gain · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)
Resorbable barrier (guided bone regeneration) showed no clear difference in bone gain (vertical - VDH) compared with non-resorbable barrier (guided bone regeneration); GRADE not reported.
1 finding from 1 review
All treatments resulted in statistically significant bone gain, however no statistically significant differences were found between the three procedures (Chen 2005a). Vertical height of the defect (VDH).
1 study · 23 participants
GRADE not reported
Jaw pain (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral cyclobenzaprine (muscle relaxant) showed no clear difference in jaw pain (VAS) compared with placebo; GRADE not reported.
1 finding from 1 review
Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
Higher total dose radiotherapy (76.8 Gy over 6.4 weeks) showed no clear difference in total mortality compared with conventional/standard total dose radiotherapy (72 Gy); GRADE not reported.
1 finding from 1 review
HR 1.08 [0.69, 1.70]
1 study
GRADE not reported
Daily mean opiate intake per hour · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Alfentanil led to lower daily mean opiate intake per hour compared with morphine; GRADE not reported.
1 finding from 1 review
Clinical: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis
Clotrimazole (partially absorbed from GI tract) showed no clear difference in clinical: eradication of oral candidiasis compared with placebo; GRADE not reported.
1 finding from 1 review
Reduction in pain intensity · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral propranolol (beta-blocker) led to lower reduction in pain intensity (percentage of patients responding) compared with placebo; GRADE not reported.
2 findings from 1 review
Tchivileva et al 2010: a significantly greater percentage of patients (67.5% versus 32.5%) experienced reduction in pain intensity rating during the propranolol treatment period than the placebo treatment period (P =…
1 study · 40 participants
GRADE not reported
Tchivileva et al 2010: Reduction in pain intensity rating (primary outcome) comparing propranolol treatment to placebo treatment did not reach statistical significance (P = 0.104); pairwise differences between…
1 study · 40 participants
GRADE not reported
Vertical bone gain · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)
Resorbable barrier (guided bone regeneration) showed no clear difference in bone gain (vertical - VDH) compared with resorbable barrier + autogenous bone; GRADE not reported.
1 finding from 1 review
All treatments resulted in statistically significant bone gain, however no statistically significant differences were found between the three procedures (Chen 2005a). Vertical height of the defect (VDH).
1 study · 24 participants
GRADE not reported
Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
Hyperfractionated/accelerated/split-course radiotherapy showed no clear difference in total mortality compared with conventional (standard) fractionation radiotherapy; GRADE not reported.
1 finding from 1 review
Bone gain (horizontal - HDD) · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)
Resorbable barrier (guided bone regeneration) showed no clear difference in bone gain (horizontal - HDD) compared with resorbable barrier + autogenous bone; GRADE not reported.
1 finding from 1 review
All treatments resulted in statistically significant bone gain, however no statistically significant differences were found between the three procedures (Chen 2005a). Horizontal depth of the defect (HDD).
1 study · 24 participants
GRADE not reported
Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Therapist support (visits) showed no clear difference in average pain scores (0-100 VAS) compared with control (treatment as usual); GRADE not reported.
1 finding from 1 review
Mycological: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis
Fluconazole (absorbed from GI tract) led to higher mycological: eradication of oral candidiasis compared with itraconazole (absorbed from GI tract); GRADE not reported.
1 finding from 1 review
Major complications at the implant/donor site · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)
Resorbable barrier (guided bone regeneration) led to lower major complications at the implant/donor site compared with resorbable barrier + autogenous bone; GRADE not reported.
1 finding from 1 review
Four complications occurred: two dehiscences in the resorbable group; one abscess and one dehiscence in the resorbable + autogenous bone group; none in the non-resorbable group. No statistically significant differences…
1 study · 24 participants
GRADE not reported
Aesthetics assessed by dentist: interproximal papilla dimension · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets
Immediate-delayed implants (placed within 8 weeks after tooth… led to lower aesthetics assessed by dentist: interproximal papilla dimension compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.
1 finding from 1 review
Improvement in mucositis · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Tetrachlorodecaoxide showed no clear difference in improvement in mucositis compared with placebo; GRADE not reported.
1 finding from 1 review
Improvement in mucositis · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Sucralfate showed no clear difference in improvement in mucositis compared with placebo; GRADE not reported.
1 finding from 1 review
Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
Morning radiotherapy showed no clear difference in total mortality compared with afternoon radiotherapy; GRADE not reported.
1 finding from 1 review
Implant failure · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets
Immediate-delayed implants (placed within 8 weeks after tooth… led to lower implant failure compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.
1 finding from 1 review
Three early implant failures (two immediate-delayed, one delayed); no statistically significant difference up to 5 years (Schropp 2003).
1 study · 46 participants
GRADE not reported
Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Chlorhexidine mouthwash showed no clear difference in average pain scores (0-100 VAS) compared with salt and soda mouthwash; GRADE not reported.
1 finding from 1 review
Mucositis severity (mild to moderate) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Low level laser therapy led to higher mucositis severity (mild to moderate) compared with sham (placebo) laser treatment; GRADE not reported.
1 finding from 1 review
Major complication at augmented site · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)
Bio-Oss (anorganic bovine bone) led to lower major complications at the augmented site compared with bio-Oss + resorbable barrier; GRADE not reported.
1 finding from 1 review
Two complications occurred in the Bio-Oss plus barrier group (one abscess during healing; one chronic perimplant mucositis); none in the Bio-Oss group. No statistically significant difference.
1 study · 20 participants
GRADE not reported