Findings

What do systematic reviews say?

2,805 questions · 2,912 findings · 307 reviews · Headline outcomes only

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No studies found 706 · 24.2%GRADE not reported 133 · 4.6%Very low 786 · 27%Low 696 · 23.9%Moderate 474 · 16.3%High 117 · 4%

Intervention not reported

Any CIN2+ irrespective of HPV type · adolescent girls and women aged 15 to 26 years who are hrHPV negative before vaccination

The intervention leads to lower any CIN2+ irrespective of HPV type (high certainty).

1 finding from 1 review

Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors 2018 · Cochrane Headline outcomes only
RR 0.33 [0.25, 0.43]
4 studies · 15884 participants
High

Intervention not reported

Any CIN3+ irrespective of HPV type, bivalent or quadrivalent vaccine · adolescent girls and women aged 15 to 26 years who are hrHPV negative before vaccination

The intervention showed no clear difference in any CIN3+ irrespective of HPV type, bivalent or quadrivalent vaccine (moderate certainty).

1 finding from 1 review

Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors 2018 · Cochrane Headline outcomes only
RR 0.21 [0.04, 1.1]
3 studies · 20719 participants
Moderate

Intervention not reported

Any CIN3+ irrespective of HPV type · adolescent girls and women aged 15 to 26 years who are hrHPV negative before vaccination

The intervention leads to lower any CIN3+ irrespective of HPV type (high certainty).

1 finding from 1 review

Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors 2018 · Cochrane Headline outcomes only
RR 0.08 [0.03, 0.23]
2 studies · 11423 participants
High

Intervention not reported

Any AIS irrespective of HPV type · adolescent girls and women aged 15 to 26 years who are hrHPV negative before vaccination

The intervention probably leads to lower any AIS irrespective of HPV type (moderate certainty).

1 finding from 1 review

Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors 2018 · Cochrane Headline outcomes only
RR 0.1 [0.01, 0.76]
2 studies · 20214 participants
Moderate

Educational or behavioural interventions for patients vs usual care

Systolic blood pressure · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 1398 participants
Moderate

Organisational interventions vs usual care

Blood pressure target achievement · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

Organisational interventions probably leads to higher blood pressure target achievement compared with usual care (moderate certainty).

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
OR 1.44 [1.09, 1.9]
13 studies · 23631 participants
Moderate

Organisational interventions vs usual care

Medication adherence (continuous) · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 5384 participants
Low

Organisational interventions vs usual care

LDL‐cholesterol · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1008 participants
Moderate

Organisational interventions vs usual care

HbA1c (%) · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 554 participants
Low

Organisational interventions vs usual care

Body‐mass index (BMI) · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1089 participants
Low

Educational or behavioural interventions for patients vs usual care

Diastolic blood pressure · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 1398 participants
Moderate

Educational or behavioural interventions for patients vs usual care

Blood pressure target achievement · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

Educational or behavioural interventions for patients showed no clear difference in blood pressure target achievement compared with usual care (moderate certainty).

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
OR 1.34 [0.7, 2.59]
3 studies · 266 participants
Moderate

Educational or behavioural interventions for patients vs usual care

Medication adherence (continuous) · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 33762 participants
Low

Educational or behavioural interventions for patients vs usual care

LDL‐cholesterol · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 495 participants
Moderate

Educational or behavioural interventions for patients vs usual care

HbA1c (%) · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 70 participants
Low

Educational or behavioural interventions for patients vs usual care

Body‐mass index (BMI) · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 127 participants
Moderate

Organisational interventions vs usual care

Systolic blood pressure · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
16 studies · 17490 participants
Moderate

Organisational interventions vs usual care

Diastolic blood pressure · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
14 studies · 17178 participants
Moderate

HALOPERIDOL vs placebo

The event rate of intensive care delirium within 28 days. · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

Haloperidol showed no clear difference in the event rate of intensive care delirium within 28 days. compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
RR 1.01 [0.87, 1.17]
1 study · 1439 participants
Moderate

HALOPERIDOL vs placebo

In‐hospital mortality within 28 days. · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

Haloperidol showed no clear difference in in‐hospital mortality within 28 days. compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
RR 0.98 [0.8, 1.22]
2 studies · 1580 participants
Moderate