Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,640 questions · 2,709 findings · 446 reviews

No studies found 593 · 21.9%GRADE not reported 241 · 8.9%Very low 538 · 19.9%Low 706 · 26.1%Moderate 516 · 19%High 115 · 4.2%

Insulin glargine vs NPH insulin

Diabetes‐related complications (1) Fatal MI (2) Fatal stroke (3) Progression in retinopathy (4) Amputations (5) ESRD

It is very uncertain whether insulin glargine changes diabetes‐related complications (1) Fatal MI (2) Fatal stroke (3)… compared with NPH insulin (very low certainty).

1 finding from 1 review

Summary of findings: insulin detemir vs NPH insulin

AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading to discontinuation

Insulin detemir showed no clear difference in AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading… compared with NPH insulin (moderate certainty).

1 finding from 1 review

Insulin glargine vs NPH insulin

AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading to discontinuation

Insulin glargine showed no clear difference in AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading… compared with NPH insulin (moderate certainty).

1 finding from 1 review