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The intervention may leads to higher objective tumour response rate (assessable participants) ‐ trials of… (low certainty).
The intervention probably leads to lower nausea/vomiting* grade 3 or 4 (safety population) by type of… (moderate certainty).
The intervention leads to higher anaemia grade 3 or 4 (safety population) by type of platinum agent… (high certainty).
The intervention leads to higher hair loss grade 3 or 4 (safety population) (high certainty).
It is very uncertain whether NSAID changes pain relief compared with placebo (very low certainty).
It is very uncertain whether NSAID changes unintended effects from treatment compared with placebo (very low certainty).
The review found no eligible studies for this question.
The review found no eligible studies for this question.
The review found no eligible studies for this question.
The review found no eligible studies for this question.
It is very uncertain whether NSAID changes requirements for additional medication compared with placebo (very low certainty).
The review found no eligible studies for this question.
Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) showed no clear difference in overall survival compared with WBRT (moderate certainty).
Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) showed no clear difference in disease‐specific survival compared with WBRT (moderate certainty).
Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) probably leads to lower local tumor control compared with WBRT (moderate certainty).
Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) showed no clear difference in functionally independent survival (KPS) compared with WBRT (moderate certainty).
Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) may leads to lower steroid use compared with WBRT (low certainty).
Modern chemotherapy regimens probably leads to lower overall survival compared with 5‐flourouracil (moderate certainty).
Irinotecan‐based regimens showed no clear difference in overall survival compared with irinotecan (low certainty).
Irinotecan‐based regimens leads to higher overall tumour response compared with irinotecan (high certainty).